INT269180

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.99
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP, TNF) extracellular region (LEP, TNF) signal transduction (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophage 1
adipocytes 1
LEP (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 99.00 Very High Very High Very High
Inflammation 10 90.48 High High
antagonist 2 77.60 Quite High
ischemia 1 13.92 Low Low
Multiple sclerosis 31 5.00 Very Low Very Low Very Low
intrathecal 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 25 99.70 Very High Very High Very High
INFLAMMATION 11 99.00 Very High Very High Very High
Cancer 1 65.20 Quite High
Sepsis 2 63.76 Quite High
Syndrome 2 60.72 Quite High
Injury 3 36.88 Quite Low
Multiple Sclerosis 37 24.16 Low Low
Cv Unclassified Under Development 1 13.92 Low Low
Disease 8 5.00 Very Low Very Low Very Low
Muscular Spasm 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinical studies demonstrated that adipocytes also directly release a constitutive amount of TNF-alpha and leptin, which are capable of inducing macrophage secretion of inflammatory mediators [42].
leptin Positive_regulation (inducing) of in adipocytes Localization (release) of TNF-alpha in macrophage associated with inflammatory mediators and obesity
1) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2679713 Disease Relevance 0.99 Pain Relevance 0.21

General Comments

This test has worked.

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