INT269185

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.75
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pecam1) cell adhesion (Pecam1) plasma membrane (Pecam1)
Anatomy Link Frequency
neuronal 2
hippocampus 2
Pecam1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 163 99.40 Very High Very High Very High
Hippocampus 48 99.40 Very High Very High Very High
Inflammation 49 97.44 Very High Very High Very High
Pyramidal cell 12 57.56 Quite High
cytokine 4 54.72 Quite High
anesthesia 3 39.24 Quite Low
Multiple sclerosis 31 28.48 Quite Low
isoflurane 3 11.52 Low Low
Central nervous system 4 5.00 Very Low Very Low Very Low
intrathecal 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 151 99.68 Very High Very High Very High
Cv Unclassified Under Development 127 99.40 Very High Very High Very High
INFLAMMATION 50 97.44 Very High Very High Very High
Death 30 82.80 Quite High
Transient Ischemic Attack 30 81.52 Quite High
Injury 6 79.80 Quite High
Adhesions 15 77.64 Quite High
Obesity 25 67.12 Quite High
Myocardial Infarction 3 60.96 Quite High
Increased Venous Pressure Under Development 1 38.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To obtain the accurate data for PECAM-1 immunoreactivity,
Regulation (data) of Gene_expression (immunoreactivity) of PECAM-1
1) Confidence 0.45 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 0.35 Pain Relevance 0.09
As mentioned previously, inflammation and infiltration of inflammatory cells are thought to be important factors in ischemia-induced neuronal damage (Gautier et al., 2009; Hendryk et al., 2010); therefore, the fact that there were no significant changes in PECAM-1 immunoreactivity and protein levels in the stress-ischemia-group may be related to the blockade of inflammatory events such as infiltration of inflammatory cells.
Neg (no) Regulation (changes) of Gene_expression (levels) of PECAM-1 in neuronal associated with stress, inflammation and ischemia
2) Confidence 0.27 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.59 Pain Relevance 0.53
In the western blot study, we found that changes in PECAM-1 protein levels in the gerbil hippocampus after ischemia/reperfusion were generally similar to the immunohistochemical change.
Regulation (changes) of Gene_expression (levels) of PECAM-1 in hippocampus associated with ischemia and hippocampus
3) Confidence 0.27 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.57 Pain Relevance 0.62
Boquest et al characterized fresh CD45 negative, CD34 positive, CD105 positive SVF cells based on CD31 expression.
Regulation (based) of Gene_expression (expression) of CD31
4) Confidence 0.09 Published 2009 Journal J Transl Med Section Body Doc Link PMC2679713 Disease Relevance 0.24 Pain Relevance 0

General Comments

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