INT26919

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 47
Total Number 48
Disease Relevance 5.86
Pain Relevance 5.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ITPR3) small molecule metabolic process (ITPR3) endoplasmic reticulum (ITPR3)
transmembrane transport (ITPR3) cytoplasm (ITPR3) signal transduction (ITPR3)
Anatomy Link Frequency
nose 7
nervous system 2
hemocyte 2
smooth muscle 1
command neurons 1
ITPR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 51 99.44 Very High Very High Very High
agonist 1073 98.80 Very High Very High Very High
Calcium channel 25 98.40 Very High Very High Very High
Mechanosensation 28 97.48 Very High Very High Very High
withdrawal 33 97.40 Very High Very High Very High
antidepressant 19 96.28 Very High Very High Very High
Kinase C 52 96.12 Very High Very High Very High
bradykinin 149 95.76 Very High Very High Very High
Enkephalin 3 94.80 High High
5HT 141 91.24 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 51 98.88 Very High Very High Very High
Anxiety Disorder 89 95.56 Very High Very High Very High
Helminth Infection 196 95.00 High High
Heart Rate Under Development 31 93.08 High High
Vomiting 8 90.40 High High
Targeted Disruption 43 89.92 High High
Headache 5 89.76 High High
Sprains And Strains 127 89.20 High High
Leiomyosarcoma 2 88.88 High High
Overactive Bladder 23 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this metabotropic model, PLC activation would lead to the production of IP3, which in turn would activate the IP3 receptor causing release of Ca2+ from the ER [15].
Gene_expression (production) of IP3
1) Confidence 0.42 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.09 Pain Relevance 0.08
When leu-EK was concomitantly added with carbachol, an additive effect was observed in IP3 generation.
Gene_expression (generation) of IP3
2) Confidence 0.32 Published 1995 Journal Chin J Physiol Section Abstract Doc Link 8697901 Disease Relevance 0.07 Pain Relevance 0.44
The octopamine-treated hemocytes were shown to increase IP3 production in the latter stage of phagocytosis.
Gene_expression (production) of IP3 in hemocytes
3) Confidence 0.30 Published 1994 Journal Arch. Insect Biochem. Physiol. Section Abstract Doc Link 8068962 Disease Relevance 0 Pain Relevance 0.25
11 suggests a reduction in IP3 levels as a result of decreased PLC?
Gene_expression (levels) of IP3
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.27 Pain Relevance 0.04
Propofol reduces the production of IP3 and can thus act as a calcium blocker preventing the entry of calcium into the vasodilatation pathway (18).
Gene_expression (production) of IP3 associated with increased venous pressure under development
5) Confidence 0.26 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908795 Disease Relevance 0.30 Pain Relevance 0.23
Second, propofol reduces the production of IP3 and calcium release from intracellular stores (16, 17), but aminophylline induced Ca2+ release from intracellular stores, occurs via increased production of IP3 through G-protein-mediated activation (21, 25).
Gene_expression (production) of IP3
6) Confidence 0.26 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908795 Disease Relevance 0.80 Pain Relevance 0.30
As Figure 5A shows, when the IP3 super sponge is expressed under control of the sra-6 promoter, the response to nose touch is disrupted.
Gene_expression (expressed) of IP3 in nose
7) Confidence 0.25 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.09 Pain Relevance 0
For some of these functions, we have some insights into the nature of events upstream of itr-1 and in particular into the member(s) of the phospholipase C (PLC) family responsible for IP3 production (Figure 1A).
Gene_expression (production) of IP3
8) Confidence 0.25 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.06 Pain Relevance 0
catalyse the production of two second messengers, IP3 and diacylglycerol (DAG), we wished to demonstrate that it is via the generation of an IP3 signal that they function in the nose touch response.
Gene_expression (production) of IP3 in nose
9) Confidence 0.25 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0 Pain Relevance 0
IP3Rs in Caenorhabditis elegans are encoded by a single gene, itr-1, and are widely expressed throughout the animal, including in the nervous system [12]–[14].
Gene_expression (expressed) of IP3Rs in nervous system
10) Confidence 0.25 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.06 Pain Relevance 0.18
(PLC-3), which catalyse the production of IP3, both function upstream of ITR-1 in the response to nose touch.
Gene_expression (production) of IP3 in nose
11) Confidence 0.25 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2729924 Disease Relevance 0 Pain Relevance 0.04
Thus, disruption of IP3 signalling in ASH, but not the command neurons, interferes with the response to nose touch.
Gene_expression (signalling) of IP3 in command neurons
12) Confidence 0.25 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.08 Pain Relevance 0
This action is transduced by the production of inositol triphosphate (IP3) through the G-protein-mediated activation of phospholipase C (12).
Gene_expression (production) of IP3
13) Confidence 0.23 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908795 Disease Relevance 0.07 Pain Relevance 0
Second, propofol reduces the production of IP3 and calcium release from intracellular stores (16, 17), but aminophylline induced Ca2+ release from intracellular stores, occurs via increased production of IP3 through G-protein-mediated activation (21, 25).
Gene_expression (production) of IP3
14) Confidence 0.23 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908795 Disease Relevance 0.72 Pain Relevance 0.31
Similarly, 5-HT enhanced IP3 production with a maximal effect at 10 nM.
Gene_expression (production) of IP3
15) Confidence 0.23 Published 1994 Journal Arch. Insect Biochem. Physiol. Section Abstract Doc Link 8068962 Disease Relevance 0 Pain Relevance 0.08
In the present study, we examined the ability of 5-HT and octopamine to enhance inositol trisphosphate (IP3) production using hemocyte membranes of the American cockroach, Periplaneta americana.
Gene_expression (production) of IP3 in hemocyte
16) Confidence 0.23 Published 1994 Journal Arch. Insect Biochem. Physiol. Section Abstract Doc Link 8068962 Disease Relevance 0 Pain Relevance 0.07
Octopamine enhanced IP3 production with a maximal peak at 100 nM.
Gene_expression (production) of IP3
17) Confidence 0.23 Published 1994 Journal Arch. Insect Biochem. Physiol. Section Abstract Doc Link 8068962 Disease Relevance 0 Pain Relevance 0.08
One possibility is that IP3 signalling in ASH lies downstream of ligand independent activation of GPCRs.
Gene_expression (signalling) of IP3
18) Confidence 0.21 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0 Pain Relevance 0.08
Our evidence indicates that, for nose touch, two PLCs, PLC-3 and EGL-8, act as the source of IP3 upstream.
Gene_expression (source) of IP3 in nose
19) Confidence 0.19 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.40 Pain Relevance 0
PLCs catalyse the hydrolysis of PIP2, to produce IP3 (Figure 1) and are therefore good candidates for the source of signal that activates the IP3R.
Gene_expression (produce) of IP3
20) Confidence 0.19 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox