INT269191

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1, Grin3a) signal transduction (Grin3a) enzyme binding (Grin1)
cytoplasm (Grin1)
Grin1 (Rattus norvegicus)
Grin3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 26 99.66 Very High Very High Very High
amygdala 28 93.12 High High
Pain 19 89.52 High High
antagonist 4 87.12 High High
Arthritis 15 65.12 Quite High
Glutamate receptor 27 50.00 Quite Low
Glutamate 15 32.76 Quite Low
nMDA receptor antagonist 11 25.00 Low Low
Anterior cingulate cortex 8 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 87 92.84 High High
Pain 19 89.52 High High
Targeted Disruption 2 74.16 Quite High
Arthritis 15 65.12 Quite High
Ganglion Cysts 5 64.92 Quite High
Toxicity 1 31.80 Quite Low
Diabetic Retinopathy 9 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Blindness 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrophysiological studies have shown that the NR3A subunit can co-assemble with NR1 and NR2A to form functional NMDA receptors with decreased NMDA receptor activity and decreased Ca2+ flux [47,48]; mice lacking the NR3A subunit show enhanced NMDA receptor activity [46].
NR1 Binding (assemble) of NR3A associated with nmda receptor
1) Confidence 0.32 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.67 Pain Relevance 0.30
Functional NMDA receptors are heteromeric assemblies of NR1 with NR2A-D or NR3A, B subunits.
NR1 Binding (assemblies) of NR3A associated with nmda receptor
2) Confidence 0.06 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2679723 Disease Relevance 0.37 Pain Relevance 0.79

General Comments

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