INT269199

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prkaca, Grin1) cytoplasm (Prkaca, Grin1) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) nucleus (Prkaca) enzyme binding (Grin1)
Anatomy Link Frequency
nucleus 2
Prkaca (Mus musculus)
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 15 100.00 Very High Very High Very High
amygdala 28 99.96 Very High Very High Very High
Pain 19 98.16 Very High Very High Very High
antagonist 4 89.52 High High
Arthritis 15 78.52 Quite High
nMDA receptor antagonist 11 51.72 Quite High
Anterior cingulate cortex 8 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
c fibre 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 19 98.16 Very High Very High Very High
Arthritis 15 78.52 Quite High
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Inflammatory Pain 1 5.00 Very Low Very Low Very Low
Stroke 1 5.00 Very Low Very Low Very Low
Paralysis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NR2B receptor blockade inhibits pain-related sensitization of amygdala neurons

Pain-related sensitization and synaptic plasticity in the central nucleus of the amygdala (CeA) depend on the endogenous activation of NMDA receptors and phosphorylation of the NR1 subunit through a PKA-dependent mechanism.

PKA Positive_regulation (depend) of Phosphorylation (phosphorylation) of NR1 in nucleus associated with pain, nmda receptor and amygdala
1) Confidence 0.03 Published 2009 Journal Mol Pain Section Title Doc Link PMC2679723 Disease Relevance 0.56 Pain Relevance 1.05

General Comments

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