INT269217

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Context Info
Confidence 0.76
First Reported 2009
Last Reported 2010
Negated 4
Speculated 6
Reported most in Body
Documents 81
Total Number 87
Disease Relevance 80.49
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SNAI1) intracellular (SNAI1) cytoplasm (SNAI1)
Anatomy Link Frequency
stroma 23
lymph node 5
colon 3
impression 1
epithelial cells 1
SNAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 45 99.76 Very High Very High Very High
Inflammation 268 99.48 Very High Very High Very High
cytokine 48 97.80 Very High Very High Very High
palliative 85 87.68 High High
chemokine 45 75.12 Quite High
Snapping jaw 14 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Hypoesthesia 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 7210 100.00 Very High Very High Very High
Breast Cancer 47 99.98 Very High Very High Very High
Colon Cancer 674 99.86 Very High Very High Very High
Skin Cancer 845 99.84 Very High Very High Very High
Adenocarcinoma 90 99.84 Very High Very High Very High
Internal Fibrosis 45 99.76 Very High Very High Very High
Confusion 40 99.52 Very High Very High Very High
Metastasis 1470 99.48 Very High Very High Very High
INFLAMMATION 266 99.48 Very High Very High Very High
Endometroid Carcinoma 45 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, in breast tumours expression of Snail1 has been associated with relapse [20].
Gene_expression (expression) of Snail1 associated with breast cancer and recurrence
1) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.66 Pain Relevance 0.09
Such a higher expression of Snail1 in areas of ulceration has been detected by other authors using a different MAb [19] and might be due to the response of epithelial cells to cytokines secreted by recruited inflammatory cells.
Gene_expression (expression) of Snail1 in epithelial cells associated with inflammation and cytokine
2) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.84 Pain Relevance 0.12
Nuclear expression of Snail1 was more abundant in the stroma.
Gene_expression (expression) of Snail1 in stroma
3) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.61 Pain Relevance 0.04
Analyses of Snail1 gene expression in different types of human tumours have been reported [see 3 for a review].
Gene_expression (expression) of Snail1 associated with cancer
4) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.76 Pain Relevance 0.10
A range of possibilities may explain how Snail1 expression in the stroma, even at lower levels, decreases survival.
Gene_expression (expression) of Snail1 in stroma
5) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.80 Pain Relevance 0
No significant correlation was found between the expression of Snail1 in the tumour and the tumour stage when we compared columns T+/S?
Gene_expression (expression) of Snail1 associated with cancer
6) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.94 Pain Relevance 0.04
The associations between Snail1 expression and other clinicopathologic variables were assessed by the Chi-square test using categorical variables.
Gene_expression (expression) of Snail1
7) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.29 Pain Relevance 0.03
It is possible that Snail1 is expressed in cells that already have undergone an almost complete EMT and have already evaded from the tumour.
Gene_expression (expressed) of Snail1 associated with cancer
8) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.74 Pain Relevance 0
Ninety tumours (56%) showed nuclear expression in the tumoral tissue and the adjacent stroma; in 34 (21%), Snail1 was detected just in the stroma, whereas in only 4 the expression of Snail1 was detected in the tumoral tissue and the stroma was negative.
Gene_expression (detected) of Snail1 in stroma associated with cancer
9) Confidence 0.76 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2680015 Disease Relevance 0.84 Pain Relevance 0
The percentage of immunoreactive cells in the specimens was variable but expression of Snail1 in positive cases was focalized and detected in areas of invasion or mucosal erosion and ulceration (see Figure 1P).
Gene_expression (expression) of Snail1
10) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.82 Pain Relevance 0.10
Using a monoclonal antibody developed in our laboratories, we have analysed the nuclear expression of Snail1 transcriptional factor in human colon tumours.
Spec (analysed) Gene_expression (expression) of Snail1 in colon associated with colon cancer
11) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.92 Pain Relevance 0.04
Another alternative would be that higher expression of Snail1 in the stroma may reflect the activation of this compartment.
Gene_expression (expression) of Snail1 in stroma
12) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.66 Pain Relevance 0
Becker and co-workers have determined the expression of Snail1 in adenocarcinomas of the upper gastrointestinal tract without detecting any significant association with clinicopathologic parameters [19].
Spec (determined) Gene_expression (expression) of Snail1 in upper associated with adenocarcinoma
13) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.50 Pain Relevance 0
Therefore, although Snail1 expression would be limited to the cells that are going through (or have just undergone) EMT, analysis of this factor in the stroma will indicate how many cells have escaped from the tumour and are capable of invading the basal lamina and later on colonize distant target organs.
Gene_expression (expression) of Snail1 in basal lamina associated with cancer
14) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.68 Pain Relevance 0
Therefore, the expression of Snail1 would potentially help to identify patients with a worse prognosis and maybe suitable for chemotherapy, a treatment not applied to all early stages colorectal tumours.
Gene_expression (expression) of Snail1 associated with colorectal cancer
15) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.98 Pain Relevance 0
Expression of Snail1 RNA has been associated to the pathogenesis of a number of malignancies; however, the lack of good monoclonal antibodies against this protein has precluded a definitive analysis of Snail1 protein.
Gene_expression (Expression) of Snail1
16) Confidence 0.76 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2680015 Disease Relevance 0.40 Pain Relevance 0
In these studies the association with survival was detected with Snail1 expression in the tumour whereas we found it with its presence in the stroma.
Gene_expression (expression) of Snail1 in stroma associated with cancer
17) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.88 Pain Relevance 0
Some other examples of cells presenting Snail1 nuclear expression are also shown.
Gene_expression (expression) of Snail1
18) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.69 Pain Relevance 0.07
Snail1 Protein in the Stroma as a New Putative Prognosis Marker for Colon Tumours

Over-expression of Snail1 gene transcriptional repressor promotes an epithelial-to-mesenchymal transition in epithelial tumour cell lines.

Gene_expression (expression) of Snail1 in Stroma associated with cancer and colon cancer
19) Confidence 0.76 Published 2009 Journal PLoS ONE Section Title Doc Link PMC2680015 Disease Relevance 0.66 Pain Relevance 0
Expression of Snail1 in the stroma correlated with lower specific survival in stage I and II tumours that display variable prognosis.
Gene_expression (Expression) of Snail1 in stroma associated with cancer
20) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 1.12 Pain Relevance 0

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