INT269220

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.07
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ITK) signal transduction (ITK) cytoplasm (ITK)
Anatomy Link Frequency
extracellular matrix 4
embryos 2
ITK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 96.96 Very High Very High Very High
Inflammation 8 86.48 High High
corticosteroid 2 85.76 High High
diclofenac 8 80.12 Quite High
cINOD 4 74.32 Quite High
COX-2 inhibitor 24 74.24 Quite High
fibrosis 1 59.28 Quite High
methotrexate 2 53.16 Quite High
imagery 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 89 97.80 Very High Very High Very High
Cataract 100 96.60 Very High Very High Very High
Capsule Opacification 204 93.56 High High
INFLAMMATION 12 86.48 High High
Carcinoma 5 80.48 Quite High
Hyperplasia 6 78.88 Quite High
Injury 6 78.64 Quite High
Aggression 1 72.88 Quite High
Malignant Neoplastic Disease 1 67.40 Quite High
Toxicity 18 65.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing evidence links overexpression of COX-2 to EMT during embryonic development, fetal implantation, and tumor formation and invasion [8,28-30].
Positive_regulation (overexpression) of Gene_expression (overexpression) of EMT associated with cancer
1) Confidence 0.14 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 1.05 Pain Relevance 0.38
Taken together, these results indicated COX-2 expression was upregulated in LEC undergoing EMT.


Positive_regulation (upregulated) of Gene_expression (undergoing) of EMT
2) Confidence 0.12 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.38 Pain Relevance 0
Postoperatively, the primary response of the remaining LEC is to undergo EMT, proliferate, and increase production of aberrant extracellular matrix proteins.
Positive_regulation (undergo) of Gene_expression (production) of EMT in extracellular matrix
3) Confidence 0.08 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.37 Pain Relevance 0
Postoperatively, the primary response of the remaining LEC is to undergo EMT, proliferate, and increase production of aberrant extracellular matrix proteins.
Positive_regulation (increase) of Gene_expression (production) of EMT in extracellular matrix
4) Confidence 0.08 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.37 Pain Relevance 0
Among them, an essential role for Snail1 has been highlighted by the general induction of the expression of this gene during EMT in many cell lines and especially by the lack of E-cadherin down-regulation during gastrulation of Snail1 deficient murine embryos [3].
Positive_regulation (induction) of Gene_expression (expression) of EMT in embryos
5) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.90 Pain Relevance 0.03

General Comments

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