INT269227

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.86
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (LOXL2) extracellular space (LOXL2) oxidoreductase activity (LOXL2)
aging (LOXL2) extracellular region (LOXL2) cell adhesion (LOXL2)
Anatomy Link Frequency
colon 1
fibroblasts 1
LOXL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2 59.76 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 75 99.16 Very High Very High Very High
Colon Cancer 15 97.12 Very High Very High Very High
Repression 1 96.60 Very High Very High Very High
Skin Cancer 1 94.28 High High
Aging 57 92.40 High High
Ovarian Cancer 2 83.28 Quite High
Endometroid Carcinoma 1 81.12 Quite High
Intervertebral Disk Degeneration 8 76.60 Quite High
Necrosis 4 74.80 Quite High
Apoptosis 8 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The second significantly upregulated gene was lysyl oxidase-like 2 (LOXL2), which has been seen to be expressed in senescent human fibroblasts [24,25].
Gene_expression (expressed) of LOXL2 in fibroblasts
1) Confidence 0.42 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.80 Pain Relevance 0.03
For example, expression of Lysyl oxidase-like 2 protein in Snail1- positive tumour cells may modulate the effects of Snail1 in colon tumour cells, as it has been demonstrated in a recent study with squamous cell carcinomas [23].
Gene_expression (expression) of oxidase-like 2 protein in colon associated with cancer, colon cancer and skin cancer
2) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 1.06 Pain Relevance 0

General Comments

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