INT269229

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.62
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ITK) signal transduction (ITK) cytoplasm (ITK)
Anatomy Link Frequency
embryo 1
ITK (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1 95.16 Very High Very High Very High
tolerance 4 43.80 Quite Low
cytokine 41 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 526 99.68 Very High Very High Very High
Pathologic Processes 1 97.64 Very High Very High Very High
Metastasis 50 96.20 Very High Very High Very High
Internal Fibrosis 1 95.40 Very High Very High Very High
Malignant Neoplastic Disease 5 77.72 Quite High
Targeted Disruption 10 74.24 Quite High
Repression 3 69.32 Quite High
Cervical Cancer 4 67.20 Quite High
Carcinoma 12 63.60 Quite High
Reprotox - General 1 10 61.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to this essential role of Snail1 in the modulation of EMT, expression of this factor has been associated to several pathological processes, such as tumour invasion [3] and renal fibrosis [4].
Regulation (modulation) of EMT associated with fibrosis, pathologic processes, cancer and internal fibrosis
1) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.57 Pain Relevance 0.05
However, our knowledge regarding the specifics of EMT in human neoplasms thus far remains patchy at best, a situation owing partially to the complexity of EMT regulation and the constraints posed by the use of human tissue, but also to the multitude of different study designs and analytical tools.
Regulation (regulation) of EMT associated with cancer
2) Confidence 0.03 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0.60 Pain Relevance 0
Additionally, the transcription factors Twist, Snail, and Slug, among others, which are critically involved in the control of EMT during tumor progression, could also be explored as novel tumor antigens for the targeting of metastatic disease.

5.

Regulation (control) of EMT associated with cancer and metastasis
3) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 1.62 Pain Relevance 0
Various genes normally expressed in the early embryo have been implicated in the control of the EMT triggered during tumor progression, including Twist, Snail, Slug, Goosecoid, and SIP1 [36, 37].
Regulation (control) of EMT in embryo associated with cancer
4) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.83 Pain Relevance 0

General Comments

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