INT269251

Context Info Confidence 0.26 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.02 Pain Relevance 0

nucleus (Lox, Ptk2, Lox) extracellular region (Lox, Lox) oxidoreductase activity (Lox, Lox) proteinaceous extracellular matrix (Lox, Lox) extracellular matrix organization (Ptk2) cytoplasm (Ptk2)

Lox (Mus musculus) Ptk2 (Mus musculus) Lox (Mus musculus)

Pain Link Frequency Relevance Heat imagery 15 5.00 metalloproteinase 1 5.00 ketamine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Cancer 62 98.56 Adhesions 7 97.64 Breast Cancer 22 80.56 Hypoxia 1 68.40 Metastasis 62 60.40 Osteolysis 4 5.00 Advanced Or Metastatic Breast Cancer 2 5.00 Apoptosis 1 5.00 Bacterial Respiratory Disease 1 5.00 Malignant Neoplastic Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our results suggest that LOX inhibition, perhaps by diminishing FAK activity [20], is able to suppress tumor cell-endothelial adhesion and/or extravasation.

LOX Negative_regulation (diminishing) of FAK Negative_regulation (inhibition) of LOX associated with cancer and adhesions

1) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 1.02 Pain Relevance 0

General Comments

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