INT269252

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Celf3) RNA binding (Celf3) nucleus (Celf3)
cytoplasm (Celf3)
Anatomy Link Frequency
hearts 1
Celf3 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 2 62.16 Quite High
imagery 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 140 99.44 Very High Very High Very High
Weight Gain 2 89.36 High High
Heart Rate Under Development 6 70.96 Quite High
Natriuresis 4 58.64 Quite High
Cardiomyopathy 10 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low
Dilated Cardiomyopathy 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Parkinson's Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of zinc either by adding 25 mmol/L ZnSO4 to drinking water (tested for 1 week and 1 month) or by i.p. injection with ZnSO4ยท7H2O (20 mg/kg, animals were sacrificed 24 h after injection as described in references [18], [19], gave no further increase in Etr1/Mecr mRNA in either of the Mecr transgenic line.
Neg (no) Positive_regulation (increase) of Etr1 associated with targeted disruption
1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680037 Disease Relevance 0.62 Pain Relevance 0.03
However, the demonstration of increased Etr1/Mecr in Mecr transgenic hearts failed based on both immunoblot analysis and enzyme activity assays, for discussion, see below.
Positive_regulation (increased) of Etr1 in hearts associated with targeted disruption
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680037 Disease Relevance 0.33 Pain Relevance 0

General Comments

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