INT269264

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.71
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mt1) intracellular (Mt1) lysosome (Mt1)
Anatomy Link Frequency
MT2 1
Mt1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 4 86.16 High High
Inflammation 9 85.00 Quite High
cytokine 14 61.68 Quite High
agonist 9 50.00 Quite Low
imagery 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 95 99.12 Very High Very High Very High
Targeted Disruption 282 98.32 Very High Very High Very High
Cardiovascular Disorder Under Development 4 96.16 Very High Very High Very High
Sleep Disorders 9 95.92 Very High Very High Very High
Neurodegenerative Disease 12 87.52 High High
INFLAMMATION 10 85.00 Quite High
Cardiomyopathy 20 78.76 Quite High
Adult Respiratory Distress Syndrome 4 74.32 Quite High
Cognitive Disorder 35 70.08 Quite High
Shock 14 51.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mice, only four functional murine MT genes are known (MT-I, MT-II, MT-III, and MT-IV), and highly inducible MT-I and MT-II isoforms are coordinately regulated [47].
Regulation (regulated) of MT-I
1) Confidence 0.21 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.21 Pain Relevance 0.03
Owing to its potent effect on MT1 and MT2 receptors, ramelteon activates sleep onset by influencing the hypothalamic “sleep switch” downstream from the SCN more efficiently than melatonin itself [35].
Regulation (effect) of MT1 in MT2
2) Confidence 0.19 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 1.54 Pain Relevance 0.04
To study the in vivo function of the mitochondrial FAS in mammals, with special reference to Mecr, we generated mice overexpressing Mecr under control of the mouse metallothionein-1 promoter.
Regulation (control) of metallothionein-1
3) Confidence 0.13 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2680037 Disease Relevance 0.28 Pain Relevance 0
To shed light on the function of the human mitochondrial FAS II, we used mice as a model system and report here generation of an artificial imbalance in the expression of Mecr when it is put under the control of the mouse metallothionein-1 (MT-1) promoter.
Regulation (control) of metallothionein-1
4) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680037 Disease Relevance 0.17 Pain Relevance 0.04
To shed light on the function of the human mitochondrial FAS II, we used mice as a model system and report here generation of an artificial imbalance in the expression of Mecr when it is put under the control of the mouse metallothionein-1 (MT-1) promoter.
Regulation (control) of MT-1
5) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680037 Disease Relevance 0.17 Pain Relevance 0.04
Here we describe the generation and analysis of mice overexpressing Mecr under the control of MT-1 promoter (Figure 1B).
Regulation (control) of MT-1
6) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680037 Disease Relevance 0.34 Pain Relevance 0.04

General Comments

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