INT269274

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Context Info
Confidence 0.60
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.47
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MTNR1A) signal transducer activity (MTNR1A)
Anatomy Link Frequency
MT2 2
MTNR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
5HT 10 100.00 Very High Very High Very High
agonist 3 50.00 Quite Low
Bioavailability 5 43.68 Quite Low
nMDA receptor 4 24.00 Low Low
antagonist 6 23.08 Low Low
Glutamate 9 12.60 Low Low
Hippocampus 1 6.20 Low Low
depression 45 5.00 Very Low Very Low Very Low
antidepressant 42 5.00 Very Low Very Low Very Low
fluoxetine 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 124 99.84 Very High Very High Very High
Targeted Disruption 77 98.94 Very High Very High Very High
Parkinson's Disease 2 88.00 High High
Cognitive Disorder 28 87.24 High High
Hepatic Insufficiency 5 84.48 Quite High
Cirrhosis 3 66.60 Quite High
Depression 47 50.00 Quite Low
Cancer 3 45.40 Quite Low
Drug Induced Neurotoxicity 5 10.76 Low Low
Neurodegenerative Disease 7 10.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two lines of Mecr transgenic mice were generated and their expressions are under control of MT-I promoter.
Regulation (control) of MT-I associated with targeted disruption
1) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680037 Disease Relevance 0.68 Pain Relevance 0
The pharmacological activity of the metabolites for 5HT-2C, MT1, and MT2 receptors is not clearly established.
Regulation (metabolites) of MT1 in MT2 associated with 5ht
2) Confidence 0.38 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785860 Disease Relevance 0.22 Pain Relevance 0.05
Moreover, its MT1 and MT2 receptors are altered in AD [166].
Regulation (altered) of MT1 in MT2 associated with disease
3) Confidence 0.10 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.58 Pain Relevance 0

General Comments

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