INT269372

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 23
Disease Relevance 0.25
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
Anatomy Link Frequency
tail 2
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1577 100.00 Very High Very High Very High
b2 receptor 18 76.56 Quite High
bradykinin 18 70.16 Quite High
Angina 23 5.00 Very Low Very Low Very Low
COX2 18 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 51 70.72 Quite High
Adhesions 18 66.88 Quite High
Targeted Disruption 20 58.64 Quite High
Increased Venous Pressure Under Development 59 53.04 Quite High
Stress 51 29.12 Quite Low
Hypertension 56 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 23 5.00 Very Low Very Low Very Low
Injury 18 5.00 Very Low Very Low Very Low
Asthma 18 5.00 Very Low Very Low Very Low
Apoptosis 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, through the use of TP isoform-specific siRNA, we sought to determine whether TP?
Positive_regulation (through) of Localization (use) of TP isoform
1) Confidence 0.23 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.06 Pain Relevance 0.07
itself and is entirely consistent with previous findings involving both prostacyclin- and NO-mediated desensitization of TP?
Positive_regulation (mediated) of Localization (desensitization) of TP
2) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
Consistent with those previous studies, pre-incubation with SIN-1 specifically impaired U46619-induced [Ca2+]i mobilization in HEK.TP?
Positive_regulation (incubation) of Localization (mobilization) of TP
3) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.03
activation, both the NO and prostacyclin analogues SIN-1 and Cicaprost impair TP-mediated cytoskeletal changes involving RhoA activation and cofilin phosphorylation in 1° h.AoSMCs and that they do so, at least in part, by specifically and directly targeting TP?
Positive_regulation (directly) of Localization (targeting) of TP
4) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.07 Pain Relevance 0
Hence, both the NO and prostacyclin impair TP-mediated cytoskeletal changes involving RhoA activation, F-actin polymerization and cofilin phosphorylation in 1° h.AoSMCs and they do so, at least in part, by specifically and directly targeting TP?
Positive_regulation (directly) of Localization (targeting) of TP
5) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Hence, in addition to the agonist-mediated PKC-feedback mechanism, engagement of the NO-cGMP signalling pathway through U46619-activation of the NOS/sGC/PKG pathway plays a significant role in inducing homologous desensitization of TP?
Positive_regulation (inducing) of Localization (desensitization) of TP associated with agonist
6) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.16
The involvement of Thr337, a site previously identified as a target for PKC phosphorylation [32], is consistent with a significant role for PKC in the agonist-induced desensitization of TP?
Positive_regulation (for) of Localization (desensitization) of TP associated with agonist
7) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.13
Similarly, the sGC and NOS inhibitors LY 83583 (30%) and l-NAME (40%), respectively, yielded significant impairments in agonist-induced desensitization of TP?.
Positive_regulation (induced) of Localization (desensitization) of TP associated with agonist
8) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.21
Hence, taken collectively, our data generated from the systematic Ala-scanning mutagenesis studies indicate a specific role for Ser145 located in IC2, Ser331 and Thr337 located within the C-tail domain in the agonist-induced desensitization of TP?
Positive_regulation (induced) of Localization (desensitization) of TP in tail associated with agonist
9) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.08
A critical difference between those two mechanisms is that agonist-mediated desensitization of TP?
Positive_regulation (mediated) of Localization (desensitization) of TP associated with agonist
10) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.05
Hence taken collectively, data herein indicate that agonist-induced densensitization of TP?
Positive_regulation (induced) of Localization (densensitization) of TP associated with agonist
11) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.15
In addition, Ser331, a site previously identified as a cGMP-dependent PKG site [35] has also been found to be critical for agonist-induced desensitization of TP?.


Positive_regulation (induced) of Localization (desensitization) of TP associated with agonist
12) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.25
Moreover, consistent with the role of NO/PKG in agonist-induced desensitization of TP?
Positive_regulation (induced) of Localization (desensitization) of TP associated with agonist
13) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.05
Whilst our finding herein that agonist-induced desensitization of TP?
Positive_regulation (induced) of Localization (desensitization) of TP associated with agonist
14) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.05
, clearly indicating that other factors may also contribute to agonist-induced desensitization of TP?.
Positive_regulation (induced) of Localization (desensitization) of TP associated with agonist
15) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.13
The involvement of Thr337, a site previously identified as a target for PKC phosphorylation [32], is consistent with a significant role for PKC in the agonist-induced desensitization of TP?
Positive_regulation (induced) of Localization (desensitization) of TP associated with agonist
16) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.13
may contribute to the PKG-, or indeed PKC-, induced desensitization of TP?.
Positive_regulation (induced) of Localization (desensitization) of TP
17) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.11
The involvement of Thr337, a site previously identified as a target for PKC phosphorylation [32], is consistent with a significant role for PKC in the agonist-induced desensitization of TP?
Positive_regulation (for) of Localization (desensitization) of TP associated with agonist
18) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.14
S145A , respectively, we have previously established that Ser145 actually corresponds to the GF 109203X-sensitive, PKC site that accounts for the partial agonist-induced desensitization of both TP?
Positive_regulation (induced) of Localization (desensitization) of TP associated with agonist
19) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.08
To investigate whether the second messenger-regulated protein kinases (PKs) may play a role in mediating homologous desensitization of TP?
Positive_regulation (mediating) of Localization (desensitization) of TP
20) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.11

General Comments

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