INT269373

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.06
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 207 99.98 Very High Very High Very High
imagery 6 54.80 Quite High
Angina 5 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
b2 receptor 2 5.00 Very Low Very Low Very Low
bradykinin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 60.84 Quite High
Stress 13 21.84 Low Low
Adhesions 2 20.48 Low Low
Increased Venous Pressure Under Development 9 6.64 Low Low
Hypertension 16 5.00 Very Low Very Low Very Low
Thrombosis 13 5.00 Very Low Very Low Very Low
Atherosclerosis 9 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 5 5.00 Very Low Very Low Very Low
Leukemia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with their reduced expression in the 1° h.AoSMCs, there was a significant reduction in U46619-mediated Rho activation and cofilin phosphorylation in the presence of RNAi directed to either TP?
Positive_regulation (activation) of Positive_regulation (directed) of TP
1) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.06 Pain Relevance 0
also mediated rapid RhoA activation in HEK.TP?
Positive_regulation (mediated) of Positive_regulation (activation) of TP
2) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
cells were treated according to the latter conditions but using TP?
Positive_regulation (treated) of Positive_regulation (using) of TP
3) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.03
It is noteworthy that collective mutation of those three sites to generate TP?
Positive_regulation (mutation) of Positive_regulation (generate) of TP
4) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.14
While both TP isoforms undergo rapid agonist-induced phosphorylation in response to TXA2 mimetic U46619 [20,25], TP?
Positive_regulation (induced) of Positive_regulation (response) of TP associated with agonist
5) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.21

General Comments

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