INT269381

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 0
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
Anatomy Link Frequency
platelet 2
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 711 100.00 Very High Very High Very High
antagonist 3 98.84 Very High Very High Very High
Angina 11 5.00 Very Low Very Low Very Low
COX2 8 5.00 Very Low Very Low Very Low
b2 receptor 8 5.00 Very Low Very Low Very Low
bradykinin 8 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 3 38.52 Quite Low
Atherosclerosis 9 24.28 Low Low
Hypertension 28 22.68 Low Low
Thrombosis 25 22.12 Low Low
Disease 6 10.28 Low Low
Muscular Spasm 3 6.08 Low Low
Increased Venous Pressure Under Development 27 5.00 Very Low Very Low Very Low
Stress 25 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, is also desensitized by the platelet antagonist /vasodilator nitric oxide (NO), involving direct NO/cGMP-dependent PKG phosphorylation of TP?
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of TP in platelet associated with antagonist
1) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.05
, undergoes prostacyclin- induced desensitization mediated through direct cAMP-protein kinase (PK) A phosphorylation of TP?
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TP
2) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
signaling, they do so by entirely independent mechanisms involving direct PKA- and PKG- mediated phosphorylation of TP?
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TP
3) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
S331A phosphorylation relative to basal levels in vehicle treated cells (Fig. 7B, lanes 1 and 2), agonist-induced phosphorylation of TP?
Positive_regulation (induced) of Phosphorylation (phosphorylation) of TP associated with agonist
4) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.12
Agonist-induced phosphorylation of TP?  
Positive_regulation (induced) of Phosphorylation (phosphorylation) of TP associated with agonist
5) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.25
signalling, GF 109203X quite significantly impaired agonist-induced desensitization such that the magnitude of the secondary U46619-response by TP?
Positive_regulation (induced) of Phosphorylation (response) of TP associated with agonist
6) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.16
Agonist-mediated TP phosphorylation in whole cells (1.8–2 × 106 cells/10 cm dish) was performed essentially as previously described [33].
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TP associated with agonist
7) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.13
, is subject to prostacyclin and PGD2-mediated desensitization in a mechanism involving direct protein kinase (PK) A phosphorylation of TP?
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TP
8) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
S331A cells with U46619 led to 2.5-fold increase in the level of TP?
Positive_regulation (increase) of Phosphorylation (level) of TP
9) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.15
Measurement of agonist-mediated TP phosphorylation
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TP associated with agonist
10) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.13
While both TP isoforms undergo rapid agonist-induced phosphorylation in response to TXA2 mimetic U46619 [20,25], TP?
Positive_regulation (induced) of Phosphorylation (phosphorylation) of TP associated with agonist
11) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.21

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