INT269384

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2008
Negated 10
Speculated 0
Reported most in Body
Documents 10
Total Number 18
Disease Relevance 0.47
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
Anatomy Link Frequency
tail 2
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 873 97.28 Very High Very High Very High
antagonist 9 96.80 Very High Very High Very High
Angina 18 47.88 Quite Low
b2 receptor 9 25.80 Quite Low
COX2 9 19.40 Low Low
bradykinin 9 19.40 Low Low
imagery 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 36 100.00 Very High Very High Very High
Renal Disease 9 50.08 Quite High
Hypertension 54 49.16 Quite Low
Asthma 9 48.60 Quite Low
Cv General 3 Under Development 18 47.88 Quite Low
Thrombosis 45 47.20 Quite Low
Increased Venous Pressure Under Development 36 46.36 Quite Low
Atherosclerosis 27 43.00 Quite Low
Stress 45 39.84 Quite Low
Apoptosis 9 31.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the reduced expression of TP?
Negative_regulation (reduced) of Gene_expression (expression) of TP
1) Confidence 0.23 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
reduced expression of TP?
Negative_regulation (reduced) of Gene_expression (expression) of TP
2) Confidence 0.23 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
impaired expression of TP?
Negative_regulation (impaired) of Gene_expression (expression) of TP
3) Confidence 0.23 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
To address this issue, we generated small interfering RNA (siRNA)-targeting agents to selectively disrupt or knock-down expression of TP?
Negative_regulation (disrupt) of Gene_expression (expression) of TP associated with targeted disruption
4) Confidence 0.17 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.24 Pain Relevance 0
reduced expression of TP?
Negative_regulation (reduced) of Gene_expression (expression) of TP
5) Confidence 0.17 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.09 Pain Relevance 0
reduced expression of TP?
Negative_regulation (reduced) of Gene_expression (expression) of TP
6) Confidence 0.17 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.09 Pain Relevance 0
, but not TP?
Neg (not) Negative_regulation (not) of Gene_expression (but) of TP
7) Confidence 0.17 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.03
, but not TP?
Neg (not) Negative_regulation (not) of Gene_expression (but) of TP
8) Confidence 0.17 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
, but not TP?
Neg (not) Negative_regulation (not) of Gene_expression (but) of TP
9) Confidence 0.17 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.05
, but not TP?
Neg (not) Negative_regulation (not) of Gene_expression (but) of TP
10) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.15
, but not TP?
Neg (not) Negative_regulation (not) of Gene_expression (but) of TP
11) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
, but not TP?
Neg (not) Negative_regulation (not) of Gene_expression (but) of TP
12) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
Moreover, through site-directed mutagenesis of both TP?
Negative_regulation (directed) of Gene_expression (mutagenesis) of TP
13) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.08
, but not TP?
Neg (not) Negative_regulation (not) of Gene_expression (but) of TP
14) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0.05 Pain Relevance 0.03
328 is devoid of C-tail residues of both TP?
Negative_regulation (devoid) of Gene_expression (residues) of TP in tail
15) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.10
, but not TP?
Neg (not) Negative_regulation (not) of Gene_expression (but) of TP
16) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.21
, but not TP?
Neg (not) Negative_regulation (not) of Gene_expression (but) of TP
17) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.16
, but not the TP?
Neg (not) Negative_regulation (not) of Gene_expression (but) of TP
18) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.06

General Comments

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