INT269390

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.40
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 136 77.36 Quite High
antagonist 4 17.60 Low Low
imagery 8 5.00 Very Low Very Low Very Low
Angina 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
b2 receptor 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Trepenoma Infection 111 89.36 High High
Increased Venous Pressure Under Development 7 67.60 Quite High
Hypertension 18 63.60 Quite High
Atherosclerosis 12 60.72 Quite High
Thrombosis 14 58.56 Quite High
Disease 29 50.00 Quite Low
Muscular Spasm 4 42.52 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 13 14.80 Low Low
Targeted Disruption 16 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 10µl sample was tested in duplicate using a real-time PCR that targets the DNA polymerase I gene of Tp (polA).
Regulation (targets) of Positive_regulation (targets) of Tp
1) Confidence 0.26 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.09 Pain Relevance 0
remains unaffected by either agent, at the interface of the receptor at least, the functional role of TP?
Neg (unaffected) Regulation (unaffected) of Positive_regulation (role) of TP
2) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.13 Pain Relevance 0
cells but neither agent affected such responses in HEK.TP?
Neg (neither) Regulation (affected) of Positive_regulation (responses) of TP
3) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
independently regulated RhoA activation and signaling in clonal cells over-expressing TP?
Regulation (regulated) of Positive_regulation (activation) of TP
4) Confidence 0.11 Published 2008 Journal Cellular Signalling Section Abstract Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
independently or indeed differentially modulate RhoA activation and downstream signaling, there is substantial evidence that the TP?
Regulation (modulate) of Positive_regulation (activation) of TP
5) Confidence 0.11 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.18 Pain Relevance 0.04
These data suggest that Thr337, a site previously established to act as a PKC site [32], plays a significant role in the homologous desensitization of TP?  
Regulation (role) of Positive_regulation (desensitization) of TP
6) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.07

General Comments

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