INT269401

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 2.89
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
Anatomy Link Frequency
epithelial cells 3
platelet 2
arterioles 1
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 7 92.24 High High
agonist 321 90.24 High High
Inflammation 14 86.12 High High
corticosteroid 14 81.32 Quite High
imagery 10 51.00 Quite High
b2 receptor 3 30.08 Quite Low
bradykinin 3 23.68 Low Low
Inflammatory response 4 15.52 Low Low
aspirin 6 9.84 Low Low
substance P 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rhinitis 250 99.92 Very High Very High Very High
Hypersensitivity 32 98.88 Very High Very High Very High
INFLAMMATION 12 86.12 High High
Edema 8 76.72 Quite High
Disease 14 72.20 Quite High
Adhesions 5 68.96 Quite High
Allergic Dermatitis 6 56.64 Quite High
Targeted Disruption 20 45.40 Quite Low
Injury 13 41.44 Quite Low
Atherosclerosis 15 7.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, while TP?
Regulation (Collectively) of Gene_expression (while) of TP
1) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Abstract Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
To confirm the efficacy of the siRNAs to disrupt TP?
Regulation (efficacy) of Gene_expression (disrupt) of TP
2) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.03
in HEK 293 cells, we next examined their ability to affect expression and signaling by the individual TP isoforms in h.AoSMCs.
Spec (examined) Regulation (affect) of Gene_expression (expression) of TP
3) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
independently regulated RhoA activation and signaling in clonal cells over-expressing TP?
Regulation (regulated) of Gene_expression (expressing) of TP
4) Confidence 0.11 Published 2008 Journal Cellular Signalling Section Abstract Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
plays a critical role in vascular haemostasis acting as the major TP target for regulation/inhibition by prostacyclin and NO, such as within the anucleate platelet that predominantly expresses TP?.
Regulation (role) of Gene_expression (expresses) of TP in platelet
5) Confidence 0.11 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.05
These data clearly indicate that mutation of Ser239, located within IC3, in combination with either Ser331 or Thr337 does not affect the overall level of TP?
Neg (not) Regulation (affect) of Gene_expression (level) of TP
6) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.07
signalling provides for a dynamic shut down or desensitization of signalling of the potent autocoid TXA2 by the counter-regulatory NO, while TP?
Regulation (regulatory) of Gene_expression (while) of TP
7) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
Collectively these data confirm that mutation of Ser340 in combination with either Ser331 or Thr337 does not affect the overall level of TP?
Neg (not) Regulation (affect) of Gene_expression (level) of TP
8) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
TP alpha expression has been found in human inferior turbinate tissue, specifically on the smooth muscle layers of the venous sinusoids, arterioles, epithelial cells and submucosal glands in human nasal mucosa from patients with AR and NAR.
Regulation (found) of Gene_expression (expression) of TP alpha in epithelial cells associated with rhinitis
9) Confidence 0.03 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2835646 Disease Relevance 1.44 Pain Relevance 0.28
TP alpha expression has been found in human inferior turbinate tissue, specifically on the smooth muscle layers of the venous sinusoids, arterioles, epithelial cells and submucosal glands in human nasal mucosa from patients with AR and NAR.
Regulation (found) of in arterioles Gene_expression (expression) of TP alpha in epithelial cells associated with rhinitis
10) Confidence 0.01 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2835646 Disease Relevance 1.44 Pain Relevance 0.28

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