INT269402

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 26
Disease Relevance 0.17
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
Anatomy Link Frequency
tail 1
platelet 1
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1474 100.00 Very High Very High Very High
antagonist 10 98.56 Very High Very High Very High
b2 receptor 16 79.24 Quite High
bradykinin 16 72.84 Quite High
Angina 26 5.00 Very Low Very Low Very Low
imagery 20 5.00 Very Low Very Low Very Low
COX2 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 40 62.56 Quite High
Leukemia 10 38.16 Quite Low
Atherosclerosis 30 22.24 Low Low
Hypertension 72 20.64 Low Low
Thrombosis 62 20.08 Low Low
Disease 20 8.24 Low Low
Stress 62 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 58 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 26 5.00 Very Low Very Low Very Low
Adhesions 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, is also desensitized by the platelet antagonist /vasodilator nitric oxide (NO), involving direct NO/cGMP-dependent PKG phosphorylation of TP?
Phosphorylation (phosphorylation) of TP in platelet associated with antagonist
1) Confidence 0.32 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.05
signaling, they do so by entirely independent mechanisms involving direct PKA- and PKG- mediated phosphorylation of TP?
Phosphorylation (phosphorylation) of TP
2) Confidence 0.32 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
, undergoes prostacyclin- induced desensitization mediated through direct cAMP-protein kinase (PK) A phosphorylation of TP?
Phosphorylation (phosphorylation) of TP
3) Confidence 0.32 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
also impaired U46619-mediated F-actin polymerization and cofilin phosphorylation in HEK.TP?
Phosphorylation (phosphorylation) of TP
4) Confidence 0.32 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.11 Pain Relevance 0
and/or TP?
Phosphorylation (/) of TP
5) Confidence 0.32 Published 2008 Journal Cellular Signalling Section Abstract Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
is not as such a direct target of prostacyclin- or NO-mediated phosphorylation and inhibition, their effect on TP?
Phosphorylation (phosphorylation) of TP
6) Confidence 0.25 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.06 Pain Relevance 0
Moreover, U46619-induced cofilin phosphorylation by TP?
Phosphorylation (phosphorylation) of TP
7) Confidence 0.25 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Consistent with the latter data, the PGD2 analogue BW245C and the alternative NO donor FK409 also significantly impaired U46619-mediated RhoA activation (Fig. 3C) and cofilin phosphorylation (data not shown) by TP?
Phosphorylation (phosphorylation) of TP
8) Confidence 0.25 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
-mediated [Ca2+]i mobilization and the G12/RhoGEF-dependent RhoA activation and cofilin phosphorylation by TP?
Phosphorylation (phosphorylation) of TP
9) Confidence 0.25 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.12
-mediated [Ca2+]i pathway and the Rho-dependent pathway are similar but entirely independent where NO/SIN-1-mediated desensitization occurs through a PKG-dependent mechanism involving direct phosphorylation of TP?
Phosphorylation (phosphorylation) of TP
10) Confidence 0.25 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.07
Consistent with this, KT 5823, the selective PKG inhibitor, significantly reduced U46619-induced phosphorylation of TP?
Phosphorylation (phosphorylation) of TP
11) Confidence 0.07 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.21
, is subject to prostacyclin and PGD2-mediated desensitization in a mechanism involving direct protein kinase (PK) A phosphorylation of TP?
Phosphorylation (phosphorylation) of TP
12) Confidence 0.07 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.03
Agonist-induced phosphorylation of TP?  
Phosphorylation (phosphorylation) of TP associated with agonist
13) Confidence 0.07 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.23
S331A phosphorylation relative to basal levels in vehicle treated cells (Fig. 7B, lanes 1 and 2), agonist-induced phosphorylation of TP?
Phosphorylation (phosphorylation) of TP associated with agonist
14) Confidence 0.07 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.12
but had no affect on phosphorylation of TP?
Phosphorylation (phosphorylation) of TP
15) Confidence 0.07 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.19
, such as through co-immunoprecipitation studies (Reid and Kinsella, unpublished), we cannot rule out the possibility that additional mechanisms other than direct phosphorylation of TP?
Phosphorylation (phosphorylation) of TP
16) Confidence 0.07 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.11
signalling, GF 109203X quite significantly impaired agonist-induced desensitization such that the magnitude of the secondary U46619-response by TP?
Phosphorylation (response) of TP associated with agonist
17) Confidence 0.07 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.15
S331A cells with U46619 led to 2.5-fold increase in the level of TP?
Phosphorylation (level) of TP
18) Confidence 0.07 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.15
Agonist-mediated TP phosphorylation in whole cells (1.8–2 × 106 cells/10 cm dish) was performed essentially as previously described [33].
Phosphorylation (phosphorylation) of TP associated with agonist
19) Confidence 0.07 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.13
To create HEK 293 cell lines stably over-expressing HA-epitope tagged forms of TP?
Phosphorylation (forms) of TP
20) Confidence 0.07 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0

General Comments

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