INT269406

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 1.43
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
Anatomy Link Frequency
smooth muscle cells 1
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1307 97.12 Very High Very High Very High
antagonist 23 95.76 Very High Very High Very High
b2 receptor 12 87.64 High High
bradykinin 12 81.24 Quite High
Angina 35 50.96 Quite High
imagery 46 5.00 Very Low Very Low Very Low
COX2 12 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Trepenoma Infection 111 96.32 Very High Very High Very High
Targeted Disruption 92 88.48 High High
Injury 12 87.08 High High
Hypertension 116 75.40 Quite High
Disease 67 74.40 Quite High
Thrombosis 93 73.92 Quite High
Increased Venous Pressure Under Development 59 66.28 Quite High
Sprains And Strains 14 58.16 Quite High
Coronary Artery Disease 23 54.56 Quite High
Leukemia 23 53.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings highlight the importance of timely specimen processing and handling, and show how subtle differences in technique can greatly alter the ability to amplify Tp DNA.


Tp DNA Binding (amplify) of
1) Confidence 0.31 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.30 Pain Relevance 0
Therefore, we extended our studies by investigating TP-mediated Rho activation and cytoskeletal signaling in the more physiologically relevant primary human aortic smooth muscle cells.
TP Binding (investigating) of in smooth muscle cells
2) Confidence 0.17 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.11
In keeping with this, TP?
TP Binding (keeping) of
3) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.05 Pain Relevance 0
S331A cells but had no affect on signaling by TP?
TP Binding (signaling) of
4) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.12
signaling by TP?
TP Binding (signaling) of
5) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Hence, through the use of TP isoform-specific siRNA, we sought to determine whether TP?
TP Spec (determine) Binding (determine) of
6) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.06 Pain Relevance 0.06
S329A cells but had no affect on signaling by TP?
TP Binding (signaling) of
7) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.07
signaling by TP?
TP Binding (signaling) of
8) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.05
Herein, we investigated whether TP?
TP Binding (investigated) of
9) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Abstract Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
following incubation of the 1° h.AoSMCs with the isoform-specific siRNAs, there were reductions in U46619-induced Rho activation and cofilin phosphorylation in the presence of RNAi directed to either TP but not directed to Lamin A/C (Fig. 9B).
TP Binding (directed) of
10) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
S329A cells, but had no affect on signaling by TP?
TP Binding (signaling) of
11) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.08
Hence, we next compared the effect of SIN-1 and Cicaprost on Rho-signaling by TP?
TP Binding (signaling) of
12) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.03
but had no effect on signaling by TP?
TP Binding (signaling) of
13) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
To this end, we investigated the ability of TP?
TP Binding (ability) of
14) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.34 Pain Relevance 0.05
Consistent with our findings herein in HEK.TP?
TP Binding (findings) of
15) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.09
coupling and signaling by TP?
TP Binding (coupling) of
16) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
M) each significantly impaired U46619-induced F-actin polymerization by both TP?
TP Neg (impaired) Binding (polymerization) of
17) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
S331A while having no affect on signaling by TP?
TP Binding (signaling) of
18) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.09
cells (Fig. 8A) thereby confirming the specificity of the TP?
TP Binding (specificity) of
19) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.24 Pain Relevance 0
, or indeed TP?
TP Binding (indeed) of
20) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.08 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox