INT269411

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2008
Negated 3
Speculated 5
Reported most in Body
Documents 9
Total Number 20
Disease Relevance 0.65
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
Anatomy Link Frequency
tail 4
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 970 97.72 Very High Very High Very High
Angina 20 49.92 Quite Low
imagery 20 25.04 Quite Low
COX2 10 5.00 Very Low Very Low Very Low
b2 receptor 10 5.00 Very Low Very Low Very Low
bradykinin 10 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 20 73.36 Quite High
Atherosclerosis 30 69.68 Quite High
Hypertension 60 68.08 Quite High
Thrombosis 50 67.52 Quite High
Coronary Artery Disease 10 53.52 Quite High
Muscular Spasm 10 51.48 Quite High
Cv General 3 Under Development 20 49.92 Quite Low
Myocardial Infarction 10 49.24 Quite Low
Injury 10 19.08 Low Low
Stress 50 17.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably however, in humans, but not in non-primates, TXA2 actually signals through two distinct TXA2 receptor isoforms termed TP?
Positive_regulation (termed) of Gene_expression (termed) of TP
1) Confidence 0.23 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.42 Pain Relevance 0.04
to mediate RhoA signaling in established clonal HEK 293 cell lines that over-express the individual TP isoforms [20,21] and in cultured 1° AoSMCs, a physiologically relevant cell type that expresses both TP?
Positive_regulation (mediate) of Gene_expression (express) of TP
2) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.23 Pain Relevance 0
Hence, these data clearly suggest that both TP?
Positive_regulation (Hence) of Spec (suggest) Gene_expression (suggest) of TP
3) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Moreover, our data generated in the HEK.TP?
Positive_regulation (generated) of Gene_expression (generated) of TP
4) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.06
The fact that we do not observe any measurable inhibitory effects on TP?
Neg (not) Positive_regulation (observe) of Neg (not) Spec (observe) Gene_expression (observe) of TP
5) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
Moreover, both TP?
Positive_regulation (Moreover) of Gene_expression (Moreover) of TP
6) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
and its specific site directed variants TP?
Positive_regulation (directed) of Gene_expression (directed) of TP
7) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Hence, as presented in our model (Fig. 10), we propose that as TP?
Positive_regulation (as) of Spec (propose) Gene_expression (propose) of TP
8) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
S329,331A is unaffected by SIN-1 while that signaling by TP?
Neg (unaffected) Positive_regulation (by) of Gene_expression (signaling) of TP
9) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.06
contribute to RhoA activation, our findings support the hypothesis that TP?
Positive_regulation (support) of Gene_expression (hypothesis) of TP
10) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Abstract Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
328, the truncated derivative devoid of the divergent residues of TP?
Positive_regulation (derivative) of Gene_expression (residues) of TP
11) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.21
Similarly, we also investigated the role of Ser340 in combination with Ser331 or Thr337 to generate TP?
Spec (investigated) Positive_regulation (generate) of Gene_expression (generate) of TP
12) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.07
Moreover, TP?
Positive_regulation (Moreover) of Gene_expression (Moreover) of TP
13) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.09
cells, or indeed of non-transfected HEK 293 or HEK.TP
Positive_regulation (transfected) of Gene_expression (transfected) of TP
14) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.22
Initially we investigated the role of Ser239 in combination with Ser331 or Thr337 to generate TP?
Spec (investigated) Positive_regulation (generate) of Gene_expression (generate) of TP
15) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.08
at Ser329, the very first residue within its unique C-tail domain divergent from TP?
Positive_regulation (divergent) of Gene_expression (divergent) of TP in tail
16) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.03
to generate pHM:TP?
Positive_regulation (generate) of Gene_expression (generate) of TP
17) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0
desensitization and hence, consistent with our previous data (Fig. 5A–C), we conclude that Ser239 does not contribute to TP?
Neg (not) Positive_regulation (not) of Neg (not) Gene_expression (contribute) of TP
18) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.07
receptor (FP), those phosphorylations/desensitizations occur at distinct PKC sites within the unique C-tail domains of TP?
Positive_regulation (occur) of Gene_expression (sites) of TP in tail
19) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
cells  with U46619 led to 5–7-fold increase in the level of TP?
Positive_regulation (increase) of Gene_expression (level) of TP
20) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.20

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