INT269413

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2008
Negated 3
Speculated 2
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 0
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
Anatomy Link Frequency
tail 2
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 698 100.00 Very High Very High Very High
Angina 10 5.00 Very Low Very Low Very Low
COX2 8 5.00 Very Low Very Low Very Low
b2 receptor 8 5.00 Very Low Very Low Very Low
bradykinin 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 22 11.52 Low Low
Increased Venous Pressure Under Development 26 5.00 Very Low Very Low Very Low
Hypertension 24 5.00 Very Low Very Low Very Low
Thrombosis 22 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 10 5.00 Very Low Very Low Very Low
Adhesions 8 5.00 Very Low Very Low Very Low
Injury 8 5.00 Very Low Very Low Very Low
Asthma 8 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
was also significantly impaired by either Cicaprost or SIN-1, while neither agent affected such responses in HEK.TP?
Neg (neither) Regulation (affected) of Localization (responses) of TP
1) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
is not affected by either prostacyclin or NO again suggests that the effects of both vasodilators are due to direct effects on TP?
Regulation (due) of Localization (effects) of TP
2) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.05
following secondary U46619 stimulation corresponded to approximately 40% of the primary signal. l-NAME had no significant effect on [Ca2+]i mobilization by TP
Neg (no) Regulation (effect) of Localization (mobilization) of TP
3) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.03
To assess the role of the nitric oxide (NO) pathway on U46619-mediated desensitization of TP?
Regulation (role) of Localization (desensitization) of TP
4) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.10
S145A , respectively, we have previously established that Ser145 actually corresponds to the GF 109203X-sensitive, PKC site that accounts for the partial agonist-induced desensitization of both TP?
Regulation (corresponds) of Localization (desensitization) of TP associated with agonist
5) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.08
Whilst pre-incubation with GF 109203X had no significant effect on [Ca2+]i mobilization by TP?
Neg (no) Regulation (effect) of Localization (mobilization) of TP
6) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.14
Hence, based on data presented herein, we propose a model for the mechanism of homologous desensitization of TP?
Spec (propose) Regulation (model) of Localization (desensitization) of TP
7) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.15
Hence, taken collectively, our data generated from the systematic Ala-scanning mutagenesis studies indicate a specific role for Ser145 located in IC2, Ser331 and Thr337 located within the C-tail domain in the agonist-induced desensitization of TP?
Regulation (role) of Localization (desensitization) of TP in tail associated with agonist
8) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.08
Investigation of the role of Nitric oxide signalling in homologous desensitization of TP?
Regulation (role) of Localization (desensitization) of TP
9) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.08
Hence, collectively these data suggested that whilst Ser145 within IC2 represents the PKC phospho-target residue involved in transient and partial desensitization of TP?
Spec (partial) Regulation (involved) of Spec (partial) Localization (desensitization) of TP
10) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.15

General Comments

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