INT269414

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.11
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
Anatomy Link Frequency
platelet 2
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 362 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
b2 receptor 4 79.52 Quite High
bradykinin 4 73.12 Quite High
Angina 6 5.00 Very Low Very Low Very Low
COX2 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 8 58.48 Quite High
Atherosclerosis 6 17.00 Low Low
Hypertension 16 15.40 Low Low
Thrombosis 14 14.84 Low Low
Stress 14 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 14 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 6 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Asthma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
also impaired U46619-mediated F-actin polymerization and cofilin phosphorylation in HEK.TP?
Regulation (polymerization) of Phosphorylation (phosphorylation) of TP
1) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.11 Pain Relevance 0
, is also desensitized by the platelet antagonist /vasodilator nitric oxide (NO), involving direct NO/cGMP-dependent PKG phosphorylation of TP?
Regulation (desensitized) of Phosphorylation (phosphorylation) of TP in platelet associated with antagonist
2) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.05
but had no affect on phosphorylation of TP?
Regulation (affect) of Phosphorylation (phosphorylation) of TP
3) Confidence 0.05 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.19
, such as through co-immunoprecipitation studies (Reid and Kinsella, unpublished), we cannot rule out the possibility that additional mechanisms other than direct phosphorylation of TP?
Regulation (direct) of Phosphorylation (phosphorylation) of TP
4) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.11
Measurement of agonist-mediated TP phosphorylation
Regulation (Measurement) of Phosphorylation (phosphorylation) of TP associated with agonist
5) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.13
, is subject to prostacyclin and PGD2-mediated desensitization in a mechanism involving direct protein kinase (PK) A phosphorylation of TP?
Regulation (involving) of Phosphorylation (phosphorylation) of TP
6) Confidence 0.02 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04

General Comments

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