INT269442

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GOPC, HHIP) cytoplasm (GOPC, HHIP) extracellular region (HHIP)
Golgi apparatus (GOPC) carbohydrate metabolic process (HHIP)
Anatomy Link Frequency
upper 1
GOPC (Homo sapiens)
HHIP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 530 99.34 Very High Very High Very High
imagery 35 9.56 Low Low
dopamine receptor 5 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 15 5.00 Very Low Very Low Very Low
Stroke 15 5.00 Very Low Very Low Very Low
Thrombosis 10 5.00 Very Low Very Low Very Low
Coronary Artery Disease 10 5.00 Very Low Very Low Very Low
Myocardial Infarction 10 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 5 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, while over-expression of a dominant negative form of Rab5a, namely Rab5aS34N, did not appear to affect the initial rate or overall biphasic profile of cicaprost-induced hIP internalization over the 4 h incubation period, it significantly impaired hIP internalization relative to that of the wild type Rab5a (Fig. 1F; p = 0.0003; ANOVA), with most significance at 2 and 3 h (Fig. 1E; p = 0.05 and p = 0.0001, respectively).
Fig Binding (internalization) of hIP
1) Confidence 0.01 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.03
While over-expression of Rab5a did not affect the initial rate or overall biphasic pattern of cicaprost-induced internalization of the hIP in HEK.hIP cells relative to that in non-transfected (Fig. 1A) or cells transfected with the empty control vector pcDNA3 (Fig. 1E), it significantly increased the overall level of hIP internalization (Fig. 1E, p < 0.0001; two-way ANOVA), with most significance at 2 and 3 h (Fig. 1E; p = 0.005 and p = 0.0076, respectively).
Fig Binding (internalization) of hIP
2) Confidence 0.01 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.10
Moreover, while over-expression of a dominant negative form of Rab5a, namely Rab5aS34N, did not appear to affect the initial rate or overall biphasic profile of cicaprost-induced hIP internalization over the 4 h incubation period, it significantly impaired hIP internalization relative to that of the wild type Rab5a (Fig. 1F; p = 0.0003; ANOVA), with most significance at 2 and 3 h (Fig. 1E; p = 0.05 and p = 0.0001, respectively).
Fig Binding (internalization) of hIP
3) Confidence 0.01 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.03
While over-expression of Rab5a did not affect the initial rate or overall biphasic pattern of cicaprost-induced internalization of the hIP in HEK.hIP cells relative to that in non-transfected (Fig. 1A) or cells transfected with the empty control vector pcDNA3 (Fig. 1E), it significantly increased the overall level of hIP internalization (Fig. 1E, p < 0.0001; two-way ANOVA), with most significance at 2 and 3 h (Fig. 1E; p = 0.005 and p = 0.0076, respectively).
Fig Binding (internalization) of hIP
4) Confidence 0.01 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.10
Furthermore, agonist stimulation caused an increased association between the hIP and Rab5aS34N (Fig. 5; upper panel).
Fig Binding (association) of hIP in upper associated with agonist
5) Confidence 0.01 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.26

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