INT269465

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.50
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HHIP) plasma membrane (HHIP) carbohydrate metabolic process (HHIP)
cytoplasm (HHIP)
Anatomy Link Frequency
hip 2
upper 2
HHIP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 319 99.78 Very High Very High Very High
Potency 4 47.88 Quite Low
imagery 21 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
dopamine receptor 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
backache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 82 98.60 Very High Very High Very High
Rickets 1 51.88 Quite High
Aging 1 50.00 Quite Low
Hypercalcemia 12 33.12 Quite Low
Bone Disease 3 11.60 Low Low
Cancer 6 10.64 Low Low
Disease 7 10.20 Low Low
Metabolic Bone Disease 2 9.12 Low Low
Hip Fractures 13 5.00 Very Low Very Low Very Low
Injury 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Observational studies in men with idiopathic and secondary osteoporosis suggest that intermittent cyclical etidronate therapy (Didronel PMO) increases BMD at the lumbar spine by 5%–10%, with smaller increases at the hip.
Positive_regulation (increases) of Positive_regulation (increases) of hip in hip associated with osteoporosis
1) Confidence 0.11 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686344 Disease Relevance 0.50 Pain Relevance 0
These data suggest that agonist-dependent activation of the hIP leads to direct time-dependent activation of Rab5 leading to its net translocation from the cytosolic/soluble fraction leading to its activation.
Positive_regulation (activation) of Positive_regulation (activation) of hIP associated with agonist
2) Confidence 0.05 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.29
hIP-mediated activation of Rab5
Positive_regulation (mediated) of Positive_regulation (activation) of hIP
3) Confidence 0.05 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.03
Furthermore, cicaprost-stimulation caused a further increase in hIP: Rab5aQ79L association (Fig. 5, upper panel).
Positive_regulation (caused) of Positive_regulation (increase) of hIP in upper
4) Confidence 0.04 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.30

General Comments

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