INT2695

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Context Info
Confidence 0.45
First Reported 1979
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.09
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DBH) extracellular region (DBH) cellular nitrogen compound metabolic process (DBH)
cytoplasm (DBH)
Anatomy Link Frequency
plasma 3
neuroblasts 1
DBH (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 17 100.00 Very High Very High Very High
Dopamine 17 100.00 Very High Very High Very High
anesthesia 10 100.00 Very High Very High Very High
ketamine 7 100.00 Very High Very High Very High
halothane 4 99.10 Very High Very High Very High
substance P 3 97.64 Very High Very High Very High
Enkephalin 5 97.00 Very High Very High Very High
Neuropeptide 1 95.96 Very High Very High Very High
tolerance 2 93.44 High High
Catecholamine 4 89.56 High High
Disease Link Frequency Relevance Heat
Syndrome 1 99.24 Very High Very High Very High
Syncope 4 96.72 Very High Very High Very High
Heart Rate Under Development 1 90.56 High High
Blepharoptosis 2 90.52 High High
Pressure Volume 2 Under Development 12 89.92 High High
Hypoglycemia 4 79.92 Quite High
Hypothermia 3 79.24 Quite High
Muscle Hypotonia 2 78.72 Quite High
Ganglion Cysts 1 75.00 Quite High
Disease 4 69.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of ketamine anesthesia (3 mg/kg i.v.) on cardiovascular parameters and noradrenaline, adrenaline and dopamine-beta-hydroxylase (DBH) activity in plasma were studied in 12 patients.
Regulation (effects) of dopamine-beta-hydroxylase in plasma associated with dopamine, anesthesia, ketamine and noradrenaline
1) Confidence 0.45 Published 1979 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 499313 Disease Relevance 0.09 Pain Relevance 0.52
The neuroblasts of the ganglia showed intense peroxidase immunoreactivity for TH, moderate reaction to DBH, and no reaction to PNMT.
Regulation (immunoreactivity) of DBH in neuroblasts
2) Confidence 0.44 Published 1981 Journal Cell Tissue Res. Section Abstract Doc Link 6162566 Disease Relevance 0.07 Pain Relevance 0.60
Halothane anesthesia that depress BP also produced no change in plasma DBH activity.
Neg (no) Regulation (change) of DBH in plasma associated with anesthesia and halothane
3) Confidence 0.27 Published 1992 Journal Mater Med Pol Section Abstract Doc Link 1307775 Disease Relevance 0 Pain Relevance 0.52
Changes in human plasma dopamine-beta-hydroxylase activity after ketamine and halothane anesthesia.
Regulation (Changes) of dopamine-beta-hydroxylase in plasma associated with anesthesia, dopamine, ketamine and halothane
4) Confidence 0.27 Published 1992 Journal Mater Med Pol Section Title Doc Link 1307775 Disease Relevance 0 Pain Relevance 0.56
The syndrome is caused by heterogeneous molecular alterations of the DBH gene and is inherited in an autosomal recessive manner.
Regulation (alterations) of DBH associated with syndrome
5) Confidence 0.25 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1459119 Disease Relevance 0.92 Pain Relevance 0.27

General Comments

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