INT269584

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.05
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (CFL1, ROCK1) cytoplasm (CFL1, ROCK1) cytosol (ROCK1)
signal transduction (ROCK1) Golgi apparatus (ROCK1) plasma membrane (CFL1)
CFL1 (Homo sapiens)
ROCK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 13 59.60 Quite High
Angina 1 21.20 Low Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 1 50.96 Quite High
Disease 2 44.64 Quite Low
Coronary Artery Disease 1 24.80 Low Low
Hypertension 4 23.72 Low Low
Atherosclerosis 3 21.88 Low Low
Cv General 3 Under Development 1 21.20 Low Low
Myocardial Infarction 1 20.52 Low Low
Thrombosis 3 19.60 Low Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ubiquitously expressed actin-depolymerising factor cofilin readily undergoes Rho/Rho kinase-dependent phosphorylation at Ser3 either by the LIM kinase 1/2 [3] and was used herein as a monitor of events downstream of Rho kinase in the Rho signaling cascade.
cofilin Binding (undergoes) of Rho kinase
1) Confidence 0.03 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

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