INT26962

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Context Info
Confidence 0.42
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 6.07
Pain Relevance 5.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CII 3
bone marrow 1
eosinophil 1
cortex 1
IgG-2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methotrexate 166 99.68 Very High Very High Very High
antagonist 1 99.50 Very High Very High Very High
Morphine 18 99.28 Very High Very High Very High
Neuritis 14 99.28 Very High Very High Very High
narcan 2 99.04 Very High Very High Very High
qutenza 8 98.52 Very High Very High Very High
depression 15 98.16 Very High Very High Very High
rheumatoid arthritis 68 97.44 Very High Very High Very High
mu opioid receptor 1 92.00 High High
Dynorphin 2 89.56 High High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 14 99.28 Very High Very High Very High
Depression 15 98.16 Very High Very High Very High
Rheumatoid Arthritis 68 97.44 Very High Very High Very High
Autoimmune Disease 16 93.84 High High
Multiple Sclerosis 1 92.08 High High
Hypersensitivity 19 91.84 High High
Apoptosis 1 91.44 High High
Uveitis 1 89.80 High High
Necrosis 13 89.76 High High
Cancer 13 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the monoclonal antibodies produced, IgG2c was not cytotoxic but was able to inhibit the in vitro effects of IgG2a, by blocking eosinophil degranulation and cell-mediated cytotoxicity [53, 54].
Negative_regulation (inhibit) of IgG2a in eosinophil
1) Confidence 0.42 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.70 Pain Relevance 0
Naloxone, a morphine antagonist, also produced a rather decreased (P < 0.05) uptake of IgG complexes by both MP and MC and did not inhibit the effect of morphine on the uptake of IgG complexes.
Negative_regulation (decreased) of IgG associated with antagonist, narcan and morphine
2) Confidence 0.35 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8498540 Disease Relevance 0.06 Pain Relevance 1.09
Contrary to these findings, anti-alpha-MSH IgG decreased (19-32%) [125I]-DAMGO labeling in several thalamic nuclei.
Negative_regulation (decreased) of IgG
3) Confidence 0.16 Published 1998 Journal Peptides Section Abstract Doc Link 9880075 Disease Relevance 0 Pain Relevance 0.45
The formation of specific antibodies was not affected, although the level of total IgG was decreased in PSA-sensitized rats treated with capsaicin after sensitization.
Negative_regulation (decreased) of IgG associated with qutenza
4) Confidence 0.12 Published 1989 Journal Int. Arch. Allergy Appl. Immunol. Section Abstract Doc Link 2574166 Disease Relevance 0.41 Pain Relevance 0.75
Moreover, the IgG2a level was also decreased in the MTX group.


Negative_regulation (decreased) of IgG2a associated with methotrexate
5) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.48 Pain Relevance 0.26
Anti-CII antibody levels in sera from rats treated with combination therapy were markly decreased, as were levels of IgG1, IgG2a, IgG2b and IgM.
Negative_regulation (decreased) of IgG2a in CII
6) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.54 Pain Relevance 0.25
Anti-CII antibody levels in sera from rats treated with combination therapy were markly decreased, as were levels of IgG1, IgG2a, IgG2b and IgM.
Negative_regulation (decreased) of IgG1 in CII
7) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.54 Pain Relevance 0.25
IVIg is thought to potentially accelerate the breakdown of endogenous IgG which may be mediating the autoimmune response.37 IVIg has also been shown in experimental animals to modulate B-cell migration from bone marrow to secondary lymphoid organs.38 In animal models of experimental autoimmune encephalomyelitis and autoimmune uveitis, IVIg is thought to reduce the production of interleukin-2 and interferon-?
Negative_regulation (breakdown) of IgG in bone marrow associated with multiple sclerosis and uveitis
8) Confidence 0.04 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2846143 Disease Relevance 0.91 Pain Relevance 0.13
Anti-CII antibody levels in sera from rats treated with combination therapy were markly decreased, as were levels of IgG1, IgG2a, IgG2b and IgM.
Negative_regulation (decreased) of IgG2b in CII
9) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.54 Pain Relevance 0.25
To test this, we infused the cortex with an inhibitor of Trk receptor tyrosine kinases, anti-TrkB IgG1, anti-BDNF, and anti-neurotrophin 4/5 antibodies.
Negative_regulation (inhibitor) of IgG1 in cortex
10) Confidence 0.03 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12736347 Disease Relevance 0.96 Pain Relevance 0.51
Also, in IL-10-treated EAN rats, upregulated anti-P2 IgG1 and downregulated IgG2a were observed.
Negative_regulation (downregulated) of IgG2a associated with neuritis
11) Confidence 0.01 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143372 Disease Relevance 0.93 Pain Relevance 0.94
IgG1 and IgG2a levels were measured to determine if these pathways were differentially affected and only IgG2a levels were decreased.
Negative_regulation (decreased) of IgG2a
12) Confidence 0.00 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8768720 Disease Relevance 0 Pain Relevance 0.42

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