INT269695

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.94
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpa1) transmembrane transport (Trpa1)
Anatomy Link Frequency
nociceptors 4
Trpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 48 99.08 Very High Very High Very High
qutenza 54 98.72 Very High Very High Very High
c fibre 28 98.60 Very High Very High Very High
Neuropathic pain 42 98.08 Very High Very High Very High
chronic construction injury 58 96.08 Very High Very High Very High
Action potential 62 92.72 High High
Hyperalgesia 6 89.20 High High
Inflammatory stimuli 2 89.04 High High
Inflammation 14 87.56 High High
Pain 38 83.92 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 100 98.08 Very High Very High Very High
Injury 136 96.08 Very High Very High Very High
Hypersensitivity 26 90.88 High High
Nervous System Injury 42 89.68 High High
Hyperalgesia 8 89.20 High High
INFLAMMATION 18 89.04 High High
Pain 40 83.92 Quite High
Inflammatory Pain 8 54.64 Quite High
Body Weight 2 51.52 Quite High
Nociception 34 19.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacologic blockade of TRPA1 decreases mechanically-evoked firing in rat C fiber nociceptors
Negative_regulation (decreases) of Negative_regulation (blockade) of TRPA1 in nociceptors associated with c fibre and nociceptor
1) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.18 Pain Relevance 0.97
We show here that acute pharmacological inhibition of TRPA1 substantially decreases the responsiveness of nociceptors to both formalin and mechanical force.
Negative_regulation (decreases) of Negative_regulation (inhibition) of TRPA1 in nociceptors associated with nociceptor
2) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.58 Pain Relevance 0.79
It is difficult to gauge the functional significance of TRPA1 down-regulation and its contribution to the pathophysiology of neuropathic pain.
Negative_regulation (regulation) of Negative_regulation (down) of TRPA1 associated with neuropathic pain
3) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.59 Pain Relevance 0.24
It is difficult to gauge the functional significance of TRPA1 down-regulation and its contribution to the pathophysiology of neuropathic pain.
Negative_regulation (down) of Negative_regulation (regulation) of TRPA1 associated with neuropathic pain
4) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.59 Pain Relevance 0.24

General Comments

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