INT26972

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Context Info
Confidence 0.57
First Reported 1985
Last Reported 2011
Negated 1
Speculated 4
Reported most in Body
Documents 57
Total Number 61
Disease Relevance 56.71
Pain Relevance 16.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tenc1)
Anatomy Link Frequency
plasma 5
brain 5
body 5
kidney 2
respiratory 2
Tenc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 176 100.00 Very High Very High Very High
Lasting pain 26 100.00 Very High Very High Very High
opioid receptor 79 99.78 Very High Very High Very High
Opioid 69 99.60 Very High Very High Very High
Pain 254 99.56 Very High Very High Very High
antagonist 98 99.52 Very High Very High Very High
narcan 46 99.12 Very High Very High Very High
Dynorphin 50 98.84 Very High Very High Very High
Kappa opioid receptor 4 98.72 Very High Very High Very High
Inflammation 436 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 316 100.00 Very High Very High Very High
Cancer 253 100.00 Very High Very High Very High
Neuropathic Pain 240 100.00 Very High Very High Very High
Appetite Loss 145 100.00 Very High Very High Very High
Normal Pressure Hydrocephalus 48 100.00 Very High Very High Very High
Disease 271 99.90 Very High Very High Very High
Targeted Disruption 428 99.88 Very High Very High Very High
Alzheimer's Dementia 346 99.84 Very High Very High Very High
Cv General 2 Under Development 3 99.68 Very High Very High Very High
Urological Neuroanatomy 245 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Multiple factors that stimulate clinically relevant airway inflammation, including viral infections, allergen exposure, inhalation of cigarette smoke, and other respiratory irritants, also reduce NEP activity, thus enhancing the effects of neuropeptides within the airways.
Negative_regulation (reduce) of NEP in respiratory associated with inflammation, viral infection and neuropeptide
1) Confidence 0.57 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 0.85 Pain Relevance 0.43
It has been shown that a variety of factors that stimulate clinically relevant airway inflammation, including viral infections, allergen exposure, inhalation of cigarette smoke, and other respiratory irritants, also reduce NEP activity, thus enhancing the effects of neuropeptides within the airways.
Negative_regulation (reduce) of NEP in respiratory associated with inflammation, viral infection and neuropeptide
2) Confidence 0.57 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 0.66 Pain Relevance 0.22
The current study further substantiates that inhibition of NEP exacerbates SB injury as there was a significant increase in MPO activity in CGS 24592 pretreated animals with SB injury compared to those with SB injury alone (Figure 3).
Negative_regulation (inhibition) of NEP associated with burns, injury and urological neuroanatomy
3) Confidence 0.50 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.86 Pain Relevance 0.22
We hypothesized that inhibition of NEP would exacerbate SB injury, leading to more plasma extravasation and more severe airway inflammation.
Negative_regulation (inhibition) of NEP in plasma associated with inflammation, burns and injury
4) Confidence 0.50 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.37 Pain Relevance 0.27
Inhibition of NEP by thiorphan or phosphoramidon leads to increased secretion of NEP (Edwards et al. 1999).
Negative_regulation (Inhibition) of NEP
5) Confidence 0.50 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 0.64 Pain Relevance 0.28
In conclusion, our study indicates that inhibition of NEP by CGS 24592 would exacerbate SB injury, leading to more plasma extravasation and severe airway inflammation.
Negative_regulation (inhibition) of NEP in plasma associated with inflammation, burns and injury
6) Confidence 0.50 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.06 Pain Relevance 0.30
On the basis of these observations, reduction of NEP activity may be regarded as part of a process that alters neurogenic airway responses from their physiological and protective function to a detrimental role that increases and perpetuates airway inflammation (Figure 4).
Negative_regulation (reduction) of NEP associated with inflammation
7) Confidence 0.50 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.27 Pain Relevance 0.25
The current study was undertaken to examine whether inhibition of NEP would exacerbate SB injury leading to more plasma extravasation and more severe airway inflammation.
Spec (whether) Negative_regulation (inhibition) of NEP in plasma associated with inflammation, burns and injury
8) Confidence 0.50 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.10 Pain Relevance 0.40
Concurrent and progressive loss of NEP activity might be expected to increase the intensity and duration of the pro-inflammatory effects of neuropeptides in the airways.
Negative_regulation (loss) of NEP associated with inflammation and neuropeptide
9) Confidence 0.50 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.14 Pain Relevance 0.33
In contrast, peripheral NEP, as exemplarily shown for the kidney as one of the organs with highest NEP expression, was already significantly inhibited using the lower candoxatril concentration (Figure 4d, left panel).
Negative_regulation (inhibited) of NEP in kidney
10) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 0.65 Pain Relevance 0
Importantly, this orexigenic effect of candoxatril was already observed within the first measurements and thus supports the conclusion of NEP inhibition being primarily responsible for changes in peptide hormone concentrations that led to the observed stimulation in food intake.
Negative_regulation (inhibition) of NEP
11) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 0.22 Pain Relevance 0
Although the psychological impact in diseases like anorexia nervosa might be the dominant one, further experiments should evaluate whether the inhibition of NEP or signaling of NEP-targeted orexigens can reduce the body weight loss in diseases with pathological reduction in body weight.
Spec (whether) Negative_regulation (inhibition) of NEP in body associated with body weight, disease and eating disorder
12) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 1.36 Pain Relevance 0
Furthermore, we demonstrated that inhibition of NEP in mice with cachexia delayed rapid body weight loss.
Negative_regulation (inhibition) of NEP in body associated with appetite loss and body weight
13) Confidence 0.50 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940827 Disease Relevance 1.16 Pain Relevance 0.04
If reduction of NEP activity leads to stimulation in food intake, its pharmacological inhibition should prevent a massive reduction in body weight in a model of pathological body weight loss.
Negative_regulation (reduction) of NEP in body associated with body weight
14) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 1.62 Pain Relevance 0
The growth of the primary tumor and the weight of liver, spleen and kidney at day 23 after tumor implantation were not affected by NEP inhibition.
Negative_regulation (inhibition) of NEP in kidney associated with cancer
15) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 1.94 Pain Relevance 0
Overall, these results support greater pain relief attained over the first 3 d in patients with acute otitis externa treated with CIP/DEX compared with NPH and a rapid reduction in severe pain after initiation of treatment.
Negative_regulation (reduction) of NPH associated with pain and otitis externa
16) Confidence 0.43 Published 2007 Journal Adv Ther Section Abstract Doc Link 17660178 Disease Relevance 1.24 Pain Relevance 0.93
Thus, a deletion or a specific pharmacological inhibition of NEP may accumulate such orexigens and consequently lead to stimulated food intake and fat accumulation.
Negative_regulation (inhibition) of NEP in fat
17) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 0.65 Pain Relevance 0
When this noxious stimulus is prolonged, more epithelial cells will be lost, leading to further loss of NEP, plasma extravasation, edema, and inflammation.
Negative_regulation (loss) of NEP in plasma associated with inflammation and edema
18) Confidence 0.37 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.70 Pain Relevance 0.16
The current study indicates that NEP inhibition by CGS 24592 caused a significant increase (p<0.05) in plasma extravasation and wet/dry weight ratios 48 h after SB injury as compared to animals with SB injury alone (Figures 2 and 3).
Negative_regulation (inhibition) of NEP in plasma associated with burns and injury
19) Confidence 0.37 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.04 Pain Relevance 0.33
Previous studies have indicated increased MPO activity following NEP inhibition (Umeno et al. 1989; Barbara et al. 2003).
Negative_regulation (inhibition) of NEP associated with urological neuroanatomy
20) Confidence 0.37 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.73 Pain Relevance 0.24

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