INT26973

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Context Info
Confidence 0.66
First Reported 1989
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 59
Total Number 60
Disease Relevance 27.19
Pain Relevance 12.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tenc1)
Anatomy Link Frequency
brain 7
liver 3
uterus 3
lung 3
epithelial cells 2
Tenc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 424 100.00 Very High Very High Very High
Neuropathic pain 254 100.00 Very High Very High Very High
Enkephalin 33 100.00 Very High Very High Very High
painful pain 28 100.00 Very High Very High Very High
medulla 26 100.00 Very High Very High Very High
Opioid 21 100.00 Very High Very High Very High
Delta opioid receptors 1 100.00 Very High Very High Very High
Hyperalgesia 30 99.72 Very High Very High Very High
Pain 338 99.52 Very High Very High Very High
Lasting pain 35 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 729 100.00 Very High Very High Very High
Neuropathic Pain 351 100.00 Very High Very High Very High
Cognitive Disorder 219 100.00 Very High Very High Very High
Syndrome 51 100.00 Very High Very High Very High
Normal Pressure Hydrocephalus 48 100.00 Very High Very High Very High
Nociception 42 100.00 Very High Very High Very High
Aging 33 100.00 Very High Very High Very High
Adhesions 4 100.00 Very High Very High Very High
Disease 996 99.84 Very High Very High Very High
Death 105 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the lung, NEP is abundantly expressed in epithelial cells (Johnson et al. 1985).
Gene_expression (expressed) of NEP in epithelial cells
1) Confidence 0.66 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 0.64 Pain Relevance 0.28
The local concentration of released neuropeptides depends on both release and degradation, and the principal degradative enzyme is NEP, which is abundantly expressed in epithelial cells of the lung (Johnson et al. 1985).
Gene_expression (expressed) of NEP in lung associated with neuropeptide
2) Confidence 0.66 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 0.84 Pain Relevance 0.42
In contrast, peripheral NEP, as exemplarily shown for the kidney as one of the organs with highest NEP expression, was already significantly inhibited using the lower candoxatril concentration (Figure 4d, left panel).
Gene_expression (expression) of NEP in kidney
3) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 0.53 Pain Relevance 0
Neutral endopeptidase (NEP), also known as neprilysin, is considered to be one of the key enzymes in the metabolism of many active peptide hormones.


Gene_expression (one) of NEP
4) Confidence 0.65 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940827 Disease Relevance 0.67 Pain Relevance 0.03
Over the last decade, understanding of the basic mechanisms contributing to the generation of NeP in preclinical animal models has greatly improved.
Gene_expression (generation) of NeP associated with neuropathic pain
5) Confidence 0.59 Published 2005 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 16083337 Disease Relevance 0.76 Pain Relevance 1.18
This is in line with data from other investigators [3,5,20], and further supports the usefulness of the LANSS scale for detecting NeP.
Gene_expression (detecting) of NeP associated with neuropathic pain
6) Confidence 0.51 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1947963 Disease Relevance 1.47 Pain Relevance 1.04
NeP is thought to be present in ~25% of chronic pain patients [3], but remains frequently undiagnosed.
Gene_expression (present) of NeP associated with lasting pain and neuropathic pain
7) Confidence 0.51 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1947963 Disease Relevance 2.24 Pain Relevance 2.08
NEP is present in lungs, brain, intestine, and bone marrow (Roques et al. 1993).
Gene_expression (present) of NEP in brain
8) Confidence 0.51 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 0.60 Pain Relevance 0.28
When considering the above mentioned NeP and NocP syndromes, the LANSS Pain Scale was able to correctly identify 82,4% (810/983) of patients with one pain complaint, representing 84,7% sensitivity and 80,2% specificity.


Gene_expression (syndromes) of NeP associated with pain, syndrome, neuropathic pain and painful pain
9) Confidence 0.51 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1947963 Disease Relevance 2.75 Pain Relevance 1.62
Mouse lung and kidney express high levels of NEP that comigrates with transfected human NEP, whereas the liver lacks NEP expression (Figure 1A).
Gene_expression (express) of NEP in liver
10) Confidence 0.43 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.06 Pain Relevance 0.08
to a similar extent as wild-type NEP, we cocultured CHO cells stably expressing APP at a 1:1 ratio with CHO cells expressing either empty vector as control, wild-type NEP, or sNEP.
Gene_expression (expressing) of wild-type NEP
11) Confidence 0.43 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0
Mouse lung and kidney express high levels of NEP that comigrates with transfected human NEP, whereas the liver lacks NEP expression (Figure 1A).
Neg (lacks) Gene_expression (expression) of NEP in liver
12) Confidence 0.43 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.07 Pain Relevance 0.07
degradation assays, conditioned medium from APP-overexpressing CHO cells was combined with 10-fold concentrated conditioned medium from CHO cells overexpressing empty vector, NEP, or sNEP and incubated at 37 °C for 18 h.
Gene_expression (overexpressing) of NEP
13) Confidence 0.43 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.22 Pain Relevance 0
Because transfected NEP may run as a broad band due to its varying degrees of glycosylation, all samples were assessed in the absence or presence of PNGase F to remove N-linked glycosylation and reduce NEP immunoreactivity to a single signal.
Gene_expression (transfected) of NEP in band
14) Confidence 0.43 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0.09
In the first experiment, basal mRNA levels of mu- and delta-opioid receptors, and of opioid-degrading enzymes enkephalinase (neutral endopeptidase 24.11; NEP) and angiotensin-converting enzyme (ACE) in the brain regions of C57BL/6 and DBA/2 mice did not reveal genetically determined differences in these parameters between the two strains.
Gene_expression (levels) of NEP in brain associated with delta opioid receptors, sprains and strains and opioid
15) Confidence 0.38 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9756041 Disease Relevance 0.35 Pain Relevance 0.37
catabolism, with the NEP and sNEP conditions reducing A?
Gene_expression (conditions) of NEP
16) Confidence 0.37 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0
Mouse lung and kidney express high levels of NEP that comigrates with transfected human NEP, whereas the liver lacks NEP expression (Figure 1A).
Gene_expression (transfected) of NEP in liver
17) Confidence 0.37 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.06 Pain Relevance 0.07
As positive and negative controls, lysates from CHO cells transfected with NEP or empty vector control were examined in parallel.
Gene_expression (transfected) of NEP
18) Confidence 0.37 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0.09
Both wild-type NEP and sNEP were capable of promoting A?
Gene_expression (capable) of wild-type NEP
19) Confidence 0.37 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0
The human ACE and human NEP cDNAs have been previously described [15,35]

Cell Culture and Lentiviral Transduction

Gene_expression (cDNAs) of NEP
20) Confidence 0.37 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.38 Pain Relevance 0

General Comments

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