INT26974

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 26.01
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
plasma 8
fat 3
adipose tissues 3
cardiomyocytes 1
muscle 1
Adipoq (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 44 99.66 Very High Very High Very High
Inflammation 207 99.46 Very High Very High Very High
Chronic pancreatitis 6 98.28 Very High Very High Very High
Clonidine 3 93.20 High High
Inflammatory response 21 91.52 High High
ischemia 9 87.20 High High
Enkephalin 7 85.52 High High
Antinociceptive 2 79.52 Quite High
tolerance 90 79.36 Quite High
Osteoarthritis 108 78.48 Quite High
Disease Link Frequency Relevance Heat
Metabolic Syndrome 388 100.00 Very High Very High Very High
Adiponectin Deficiency 1 100.00 Very High Very High Very High
Obesity 914 99.84 Very High Very High Very High
Diabetes Mellitus 332 99.84 Very High Very High Very High
Insulin Resistance 366 99.70 Very High Very High Very High
INFLAMMATION 225 99.46 Very High Very High Very High
Pancreatitis 14 98.28 Very High Very High Very High
Increased Venous Pressure Under Development 21 96.52 Very High Very High Very High
Lipodystrophy 3 96.32 Very High Very High Very High
Polycystic Ovary Syndrome 2 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, the mRNA levels of adiponectin in the WAT were markedly decreased 8 weeks after the treatment with a high-fat diet, and this decrease preceded the decrease in the plasma adiponectin protein levels.
Negative_regulation (decrease) of adiponectin in fat associated with obesity
1) Confidence 0.52 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.26 Pain Relevance 0.04
Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice.
Negative_regulation (deficiency) of Adiponectin associated with chronic pancreatitis and adiponectin deficiency
2) Confidence 0.43 Published 2010 Journal J. Gastroenterol. Section Title Doc Link 20155376 Disease Relevance 0.74 Pain Relevance 0.27
Adiponectin is not only decreased in obese individuals but also in type 2 diabetic patients [7] and a low level is a risk factor for developing this disease [13].
Negative_regulation (decreased) of Adiponectin associated with diabetes mellitus, obesity and disease
3) Confidence 0.39 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.74 Pain Relevance 0
Plasma adiponectin levels rose in mice treated with BVT116429 and this was found to be both the hexameric and the high molecular weight multimeric forms of adiponectin.
Negative_regulation (rose) of adiponectin in Plasma
4) Confidence 0.39 Published 2008 Journal BMC Pharmacol Section Abstract Doc Link PMC2270815 Disease Relevance 0.54 Pain Relevance 0.04
Similar findings were reported by Yamauchi et al. [15–17], who demonstrated that adiponectin is decreased in obesity and deficient in mice that are lacking in specific adipose tissues that play a causal role in the development of insulin resistance, and that the replenishment of adiponectin might provide a novel treatment modality for insulin resistance, type 2 diabetes, and atherosclerosis.
Negative_regulation (decreased) of adiponectin in adipose tissues associated with diabetes mellitus, metabolic syndrome, increased venous pressure under development and insulin resistance
5) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.61 Pain Relevance 0.03
Similar findings were reported by Yamauchi et al. [15–17], who demonstrated that adiponectin is decreased in obesity and deficient in mice that are lacking in specific adipose tissues that play a causal role in the development of insulin resistance, and that the replenishment of adiponectin might provide a novel treatment modality for insulin resistance, type 2 diabetes, and atherosclerosis.
Negative_regulation (deficient) of adiponectin in adipose tissues associated with diabetes mellitus, metabolic syndrome, increased venous pressure under development and insulin resistance
6) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.63 Pain Relevance 0.03
In addition, the decrease in plasma adiponectin levels was correlated with the increases in plasma insulin and HOMA-IR.
Negative_regulation (decrease) of adiponectin in plasma
7) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.29 Pain Relevance 0.03
Because adiponectin is reported to be decreased in obesity, we investigated the changes in adiponectin expression in epididymal WAT and the plasma adiponectin levels in high-fat diet-fed mice (Fig. 4A and B).
Negative_regulation (decreased) of adiponectin in plasma associated with obesity and metabolic syndrome
8) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 0.82 Pain Relevance 0.08
In contrast, adiponectin, which is reduced in obesity, and has anti-inflammatory and antioxidant properties [19-21], has been shown to reduce BHR and decrease airway inflammation following OVA inhalation in mice [22].
Negative_regulation (reduced) of adiponectin associated with inflammation and obesity
9) Confidence 0.38 Published 2007 Journal Respir Res Section Body Doc Link PMC1855924 Disease Relevance 1.92 Pain Relevance 0.23
The plasma levels of adiponectin tended to decrease in mice treated with high-fat diet 14 weeks and 22 weeks of age compared with those in 6-week-old mice.


Negative_regulation (decrease) of adiponectin in plasma
10) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 0.59 Pain Relevance 0.09
The plasma adiponectin level was decreased by diabetes, and was lower in males.
Negative_regulation (decreased) of adiponectin in plasma associated with diabetes mellitus
11) Confidence 0.38 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19721331 Disease Relevance 1.05 Pain Relevance 0.23
Similar findings were reported by Yamauchi et al. [15–17], who demonstrated that adiponectin is decreased in obesity and deficient in mice that are lacking in specific adipose tissues that play a causal role in the development of insulin resistance, and that the replenishment of adiponectin might provide a novel treatment modality for insulin resistance, type 2 diabetes, and atherosclerosis.
Negative_regulation (replenishment) of adiponectin in adipose tissues associated with diabetes mellitus, metabolic syndrome, increased venous pressure under development and insulin resistance
12) Confidence 0.33 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.69 Pain Relevance 0
Highly efficient inhibitors of NEP were obtained whatever the modification on the P'2 component, while for APN inhibition, a cyclic beta-amino acid was preferred.
Negative_regulation (inhibition) of APN
13) Confidence 0.32 Published 1989 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2574715 Disease Relevance 0 Pain Relevance 0.20
Finally, a relatively modest inhibition of APN was observed with Ki's in the 0.5-1 microM range for compounds with benzyl or cyclohexyl group in P'2 position.
Negative_regulation (inhibition) of APN
14) Confidence 0.28 Published 1989 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2707969 Disease Relevance 0 Pain Relevance 0.43
As insulin resistance in response to obesity and high fat feeding has been demonstrated to arise from increased concentrations of local and circulating pro-inflammatory cytokines [21] and from a reduction of circulating adiponectin concentrations [22], [23], we determined these parameters in control- and IR?
Negative_regulation (reduction) of adiponectin in fat associated with inflammation, obesity, insulin resistance and cytokine
15) Confidence 0.28 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.92 Pain Relevance 0.17
Per unit fat mass, however, serum adiponectin concentrations at the final time point were significantly reduced with high-fat feeding: 2.79 ± 0.20 ?
Negative_regulation (reduced) of serum adiponectin in fat
16) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.52 Pain Relevance 0.22
Plasma adiponectin levels have been reported to be reduced in patients with obesity (Arita et al., 1999), type 2 diabetes (Hotta et al., 2000), and coronary vascular diseases (CVD) (Hotta et al., 2000), all of which are closely related to insulin resistance.
Negative_regulation (reduced) of adiponectin in Plasma associated with cardiovascular disease, diabetes mellitus, obesity, insulin resistance and increased venous pressure under development
17) Confidence 0.26 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2849047 Disease Relevance 0.91 Pain Relevance 0.04
Thus, the decrease of adiponectin level, associated with obesity, also contributes to endothelial dysfunction in metabolic syndrome [19].
Negative_regulation (decrease) of adiponectin associated with obesity and metabolic syndrome
18) Confidence 0.24 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 1.64 Pain Relevance 0.03
Plasma adiponectin levels decrease during obesity, and are negatively associated with plasma insulin, positively associated with plasma triglycerides, and correlate with increases in HOMA-IR [6].
Negative_regulation (decrease) of adiponectin in plasma associated with metabolic syndrome
19) Confidence 0.24 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 1.08 Pain Relevance 0.07
Additionally, decreased adiponectin levels have been implicated in the development of steatosis in mouse models of obesity and lipodystrophy [31].
Negative_regulation (decreased) of adiponectin associated with lipodystrophy and metabolic syndrome
20) Confidence 0.24 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 1.04 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox