INT269744

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE5A) signal transduction (PDE5A) cellular_component (PDE5A)
PDE5A (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 1 22.16 Low Low
Onset of action 5 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
backache 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 89 90.16 High High
Cv Unclassified Under Development 4 81.68 Quite High
Benign Prostatic Hypertrophy 112 75.56 Quite High
Lower Urinary Tract Symptoms 93 69.84 Quite High
Hypertension 19 62.40 Quite High
Aging 18 55.76 Quite High
Diabetes Mellitus 11 14.56 Low Low
Coronary Artery Disease 1 13.68 Low Low
Reprotox - General 1 15 9.36 Low Low
Overactive Bladder 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the patients, the factors most significantly associated with treatment preference were differences in time concerns, choice of dose, intercourse satisfaction, number of sexual attempts, satisfaction with erection hardness and the absence of or only minor side effects.19 Although preference studies have shown that all the PDE5 inhibitors were highly effective, the majority of patients seemed to prefer tadalafil because it is easier to take, can be ingested at any time of the day, and its property of enabling them to achieve an erection, with sexual stimulation, long after taking the drug (eg, 8, 16 or 24 hours later), leading to higher sexual self-confidence and spontaneity and fewer time concerns related to sexual encounters.7,19
Negative_regulation (inhibitors) of PDE5 Binding (all) of
1) Confidence 0.43 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778425 Disease Relevance 0.11 Pain Relevance 0
Current US labeling for sildenafil, tadalafil, and vardenafil states that these phosphodiesterase type 5 inhibitors should be started at the lowest recommended dose for patients stabilized on ?
Negative_regulation (inhibitors) of phosphodiesterase type 5 Binding (these) of
2) Confidence 0.03 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682383 Disease Relevance 0.63 Pain Relevance 0

General Comments

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