INT26975

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Context Info
Confidence 0.75
First Reported 1989
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 113
Total Number 117
Disease Relevance 106.71
Pain Relevance 14.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
plasma 17
fat 15
adipocytes 15
adipose tissue 7
monocytes 2
Adipoq (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1593 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
Osteoarthritis 433 99.60 Very High Very High Very High
tolerance 493 99.52 Very High Very High Very High
fibrosis 374 98.66 Very High Very High Very High
agonist 496 98.56 Very High Very High Very High
Cannabinoid receptor 186 98.56 Very High Very High Very High
chemokine 62 98.28 Very High Very High Very High
cytokine 254 97.90 Very High Very High Very High
Endocannabinoid 107 97.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 6011 100.00 Very High Very High Very High
INFLAMMATION 1792 100.00 Very High Very High Very High
Diabetes Mellitus 1619 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 184 100.00 Very High Very High Very High
Insulin Resistance 1131 99.92 Very High Very High Very High
Cancer 195 99.92 Very High Very High Very High
Metabolic Syndrome 736 99.88 Very High Very High Very High
Impaired Glucose Tolerance 468 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 112 99.84 Very High Very High Very High
Osteoarthritis 346 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To develop new adiponectin inducers, eight species of ferulic esters and amides, and five related compounds were synthesized and tested on the stimulation of adiponectin production in mouse 3T3-L1 and normal human preadipocytes.
Gene_expression (production) of adiponectin in 3T3-L1
1) Confidence 0.75 Published 2008 Journal Life Sci. Section Abstract Doc Link 18166202 Disease Relevance 0.09 Pain Relevance 0.13
Thus these three animal models implicate an association between glucocorticoid dynamics in adipose tissue and adiponectin expression.
Gene_expression (expression) of adiponectin in adipose tissue associated with obesity
2) Confidence 0.70 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.11 Pain Relevance 0.14
Another transgenic mouse overexpressing HSD type 2 in adipose tissue, and thereby inhibiting corticosterone exposure intracellularly, also had higher expression of adiponectin than its wild type counterparts when fed a high fat diet [21].
Gene_expression (expression) of adiponectin in fat associated with targeted disruption and obesity
3) Confidence 0.70 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.38 Pain Relevance 0.13
Treatment with thiazolidinediones increases the expression and secretion of adiponectin in both rodents and humans [15,16], indicating that changes in this adipokine may be integral to the therapeutic effects of thiazolidinediones [17,18].
Gene_expression (expression) of adiponectin
4) Confidence 0.70 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.04 Pain Relevance 0.06
HSD1 in adipose tissue with decreased adiponectin expression in mesenteric fat [4].
Gene_expression (expression) of adiponectin in fat associated with obesity
5) Confidence 0.70 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.00 Pain Relevance 0.12
HSD1 activity in adipocytes is able to increase adiponectin production, suggesting that the effect seen in intact mice is a direct one on the adipose mass.


Gene_expression (production) of adiponectin in adipocytes associated with obesity
6) Confidence 0.70 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.49 Pain Relevance 0.08
HSD1 -/- mice have higher expression of uncoupling protein 2 (UCP-2) when fed high fat diet and this might be due to the elevated expression in adiponectin [5].
Gene_expression (expression) of adiponectin in fat
7) Confidence 0.70 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.71 Pain Relevance 0
These data raise the possibility that the expression of adiponectin mRNA might be disturbed by the accumulation of fatty acids, and more closely related to insulin sensitivity than obesity alone.
Gene_expression (expression) of adiponectin mRNA associated with metabolic syndrome
8) Confidence 0.69 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.28 Pain Relevance 0.03
Because adiponectin is reported to be decreased in obesity, we investigated the changes in adiponectin expression in epididymal WAT and the plasma adiponectin levels in high-fat diet-fed mice (Fig. 4A and B).
Gene_expression (expression) of adiponectin in plasma associated with obesity and metabolic syndrome
9) Confidence 0.69 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 0.79 Pain Relevance 0.07
Although there were no significant differences in several parameters between the basal diet group and the high-fat diet group at the end of experiment (22-week-old mice), several characteristics of the metabolic syndrome, including visceral adipose tissue accumulation and decreased adiponectin expression were developed more earlier in the high-fat diet group compared to the basal diet group.
Gene_expression (expression) of adiponectin in visceral associated with obesity and metabolic syndrome
10) Confidence 0.69 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.31 Pain Relevance 0.04
The mRNA expression of adiponectin and its plasma levels are significantly reduced in obese/diabetic mice [13] and humans [14].
Gene_expression (expression) of adiponectin in plasma associated with diabetes mellitus and obesity
11) Confidence 0.69 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.36 Pain Relevance 0.07
The treatment with a high-fat diet markedly decreased the adiponectin mRNA expression in mice at 14 weeks of age compared to the mice before treatment, and this decrease continued in mice 22 weeks of age.
Gene_expression (expression) of adiponectin mRNA in fat
12) Confidence 0.69 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 0.63 Pain Relevance 0.07
The major finding of this study included the following: (1) the increase in visceral adipose tissue preceded development of fatty liver and insulin resistance; (2) the increase in size of white adipocytes was an early event as the fist step to obesity; (3) adiponectin mRNA expression was markedly decreased before the decrease in its plasma levels or the development of insulin resistance; and (4) insulin resistance appeared in association with fatty infiltration and TNF-?
Gene_expression (expression) of adiponectin mRNA in plasma associated with fatty liver, obesity, metabolic syndrome and insulin resistance
13) Confidence 0.69 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 0.86 Pain Relevance 0
These results suggest that the present ferulamides would be useful lead compounds in developing more potent agents for treatment of metabolic syndromes through promoting the endogenous adiponectin production, and that such an activity is possibly enhanced by the coadministration with DHA.
Gene_expression (production) of adiponectin associated with syndrome
14) Confidence 0.65 Published 2008 Journal Life Sci. Section Abstract Doc Link 18166202 Disease Relevance 0.10 Pain Relevance 0.13
The adiponectin production by 7 is synergistically enhanced by coaddition of a PPARgamma-specific agonist, pioglitazone (PGZ), or another PPARgamma agonist, docosahexaenoic acid (DHA), in cultured preadipocytes.
Gene_expression (production) of adiponectin associated with agonist
15) Confidence 0.65 Published 2008 Journal Life Sci. Section Abstract Doc Link 18166202 Disease Relevance 0.07 Pain Relevance 0.21
HSD1 inhibitor BVT2733 on adiponectin concentrations
Gene_expression (concentrations) of adiponectin
16) Confidence 0.61 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.09 Pain Relevance 0
The adiponectin levels were analyzed with a human adiponectin ELISA kit (CYT350, Chemicon Int.) according to the manufacturer's instructions.


Spec (analyzed) Gene_expression (levels) of adiponectin
17) Confidence 0.61 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.28 Pain Relevance 0.04
The mRNA expression of adiponectin is reduced in adipose tissue in obese mice and humans [12] although the picture differs somewhat depending on fat depot.
Gene_expression (expression) of adiponectin in fat associated with obesity
18) Confidence 0.61 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.64 Pain Relevance 0
BACKGROUND: Adiponectin is recognized as an antiinflammatory and antifibrotic protein derived from adipocytes, and low serum adiponectin levels are present in obesity.
Gene_expression (levels) of adiponectin in adipocytes associated with inflammation and obesity
19) Confidence 0.60 Published 2010 Journal J. Gastroenterol. Section Abstract Doc Link 20155376 Disease Relevance 0.72 Pain Relevance 0.24
In the future, it will be necessary to investigate the effects of BOF treatment on adiponectin expression or glucose tolerance in a study with a longer follow-up.
Gene_expression (expression) of adiponectin associated with tolerance and impaired glucose tolerance
20) Confidence 0.60 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.17 Pain Relevance 0.05

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