INT269758

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 4
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.15
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1, IGFBP2) extracellular space (IGF1, IGFBP2) extracellular region (IGF1, IGFBP2)
aging (IGFBP2) response to stress (IGFBP2)
IGF1 (Homo sapiens)
IGFBP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 8 82.40 Quite High
withdrawal 4 13.64 Low Low
backache 20 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 200 89.20 High High
Reprotox - General 2 16 84.64 Quite High
Apoptosis 8 74.24 Quite High
Injury 4 18.12 Low Low
Hypercalcemia 80 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 32 5.00 Very Low Very Low Very Low
Hip Fractures 20 5.00 Very Low Very Low Very Low
Low Back Pain 20 5.00 Very Low Very Low Very Low
Kidney Stones 16 5.00 Very Low Very Low Very Low
Aging 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Age-related decreases in insulin-like growth factor 1 (IGF-1) and increases in insulin-like growth factor binding protein 2 (IGFBP-2) levels may also impair bone formation directly or via an increase in serum SHBG levels (Amin et al 2004, 2007).
Negative_regulation (decreases) of insulin-like growth factor 1 Spec (may) Negative_regulation (impair) of Positive_regulation (increases) of insulin-like growth factor binding protein 2
1) Confidence 0.10 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.54 Pain Relevance 0.04
Age-related decreases in insulin-like growth factor 1 (IGF-1) and increases in insulin-like growth factor binding protein 2 (IGFBP-2) levels may also impair bone formation directly or via an increase in serum SHBG levels (Amin et al 2004, 2007).
Negative_regulation (decreases) of insulin-like growth factor 1 Spec (may) Negative_regulation (impair) of Positive_regulation (increases) of IGFBP-2
2) Confidence 0.10 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.54 Pain Relevance 0.04
Age-related decreases in insulin-like growth factor 1 (IGF-1) and increases in insulin-like growth factor binding protein 2 (IGFBP-2) levels may also impair bone formation directly or via an increase in serum SHBG levels (Amin et al 2004, 2007).
Negative_regulation (decreases) of IGF-1 Spec (may) Negative_regulation (impair) of Positive_regulation (increases) of insulin-like growth factor binding protein 2
3) Confidence 0.10 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.54 Pain Relevance 0.04
Age-related decreases in insulin-like growth factor 1 (IGF-1) and increases in insulin-like growth factor binding protein 2 (IGFBP-2) levels may also impair bone formation directly or via an increase in serum SHBG levels (Amin et al 2004, 2007).
Negative_regulation (decreases) of IGF-1 Spec (may) Negative_regulation (impair) of Positive_regulation (increases) of IGFBP-2
4) Confidence 0.10 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.54 Pain Relevance 0.04

General Comments

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