INT269768

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
plasma 2
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 59 99.54 Very High Very High Very High
Targeted Disruption 5 94.72 High High
Lifespan 3 67.68 Quite High
Death 2 52.20 Quite High
Body Weight 2 51.44 Quite High
Cancer 9 50.92 Quite High
Cognitive Disorder 2 39.76 Quite Low
Obesity 3 27.68 Quite Low
Metabolic Syndrome 1 24.40 Low Low
Diabetes Mellitus 3 20.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further support of the role of IGF-1 in aging is provided by the recent findings that deletion of pregnancy-associated plasma protein A (PAPP-A), a protease that destroys IGF-1 binding proteins, markedly increases longevity of mice presumably by reducing local availability of IGF-1 (Conover and Bale 2007).
Negative_regulation (reducing) of Negative_regulation (availability) of IGF-1 in plasma associated with aging
1) Confidence 0.08 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682398 Disease Relevance 0.96 Pain Relevance 0

General Comments

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