INT269825

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.61
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 19 97.40 Very High Very High Very High
fibrosis 34 91.52 High High
Inflammation 23 82.24 Quite High
Bile 2 73.72 Quite High
Inflammatory response 5 29.28 Quite Low
chemokine 6 23.68 Low Low
rheumatoid arthritis 1 12.04 Low Low
cytokine 7 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hydronephrosis 77 99.84 Very High Very High Very High
Injury 60 91.96 High High
Fibrosis 27 91.52 High High
INFLAMMATION 28 82.24 Quite High
Sprains And Strains 4 68.52 Quite High
Adhesions 28 65.36 Quite High
Ureteral Obstruction 36 65.28 Quite High
Renal Disease 33 53.28 Quite High
Cancer 38 51.12 Quite High
Glioma 33 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, MMP2/TIMP2 and MMP9/TIMP1 mRNA expression and MMP9 activity was considerably reduced in TLR2?
Negative_regulation (reduced) of Transcription (expression) of MMP9 associated with hydronephrosis
1) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.44 Pain Relevance 0.36
Reduction in the mRNA levels of MMP-9, uPAR and cathepsin B in M-sh, U-sh and C-sh transfected 4910 cells indicated a downregulation of MMP-9, uPAR and cathespin B target mRNAs, the mechanism by which shRNAs are proposed to work [24], [25].
Negative_regulation (Reduction) of Transcription (levels) of MMP-9
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.18 Pain Relevance 0

General Comments

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