INT269828

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 5.20
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Timp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 88 99.86 Very High Very High Very High
Inflammation 195 99.32 Very High Very High Very High
cytokine 40 98.96 Very High Very High Very High
fibrosis 111 97.52 Very High Very High Very High
Bile 6 74.16 Quite High
Inflammatory response 20 25.84 Quite Low
chemokine 26 20.24 Low Low
rheumatoid arthritis 1 12.48 Low Low
Bioavailability 13 11.64 Low Low
antagonist 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 212 99.32 Very High Very High Very High
Hydronephrosis 77 98.12 Very High Very High Very High
Fibrosis 130 97.52 Very High Very High Very High
Injury 152 96.28 Very High Very High Very High
Wound Healing 5 96.12 Very High Very High Very High
Disease 22 94.44 High High
Inflammatory Bowel Disease 2 94.32 High High
Targeted Disruption 7 91.92 High High
Cirrhosis 31 91.32 High High
Pulmonary Disease 144 87.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antagonizing TIMP-1 using both neutralizing antibodies and gene therapy, as well as indirect TIMP-1 mRNA reduction by antagonizing inflammatory cytokines improved experimental fibrosis in rodents [20].
Transcription (reduction) of TIMP-1 associated with fibrosis, inflammation and cytokine
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.25 Pain Relevance 0.47
Antagonizing TIMP-1 using both neutralizing antibodies and gene therapy, as well as indirect TIMP-1 mRNA reduction by antagonizing inflammatory cytokines improved experimental fibrosis in rodents [20].
Transcription (reduction) of TIMP-1 associated with fibrosis, inflammation and cytokine
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.28 Pain Relevance 0.48
Surprisingly, MMP2/TIMP2 and MMP9/TIMP1 mRNA expression and MMP9 activity was considerably reduced in TLR2?
Transcription (expression) of TIMP1 associated with hydronephrosis
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.42 Pain Relevance 0.35
1, CCL2, VEGF, MMP-9 and TIMP-2 protein and mRNA expression (Saika et al 2005).
Transcription (expression) of TIMP associated with metalloproteinase
4) Confidence 0.13 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.25 Pain Relevance 0.22

General Comments

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