INT269846

Context Info Confidence 0.21 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 3.19 Pain Relevance 0

cytoplasm (F3, Ncl) nucleoplasm (Ncl) extracellular space (F3) nucleolus (Ncl) RNA binding (Ncl) nucleus (Ncl)

Anatomy Link Frequency nucleus 1 F3 (Mus musculus) Ncl (Mus musculus)

Pain Link Frequency Relevance Heat imagery 12 5.00 nud 4 5.00 palliative 2 5.00 Somatostatin 2 5.00 anesthesia 2 5.00 isoflurane 2 5.00

Disease Link Frequency Relevance Heat Cancer 278 100.00 Carcinoma 48 97.88 Neuroendocrine Cancer 4 71.32 Reprotox - General 1 4 58.68 Neuroblastoma 2 57.20 Lymphatic System Cancer 2 55.92 Skin Cancer 4 55.52 Glioma 2 55.12 Leukemia 2 54.80 Ovarian Cancer 10 30.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

F3 is a 32 amino acid vascular tumor homing peptide that binds specifically to nucleolin on the surface of tumor cells [14], [15].

F3 Binding (binds) of nucleolin associated with cancer

1) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 1.75 Pain Relevance 0

F3 is a tumor homing peptide which is internalized into the nucleus of tumor cells upon binding to nucleolin on the cell surface.

F3 Binding (binding) of nucleolin in nucleus associated with cancer

2) Confidence 0.17 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682652 Disease Relevance 1.44 Pain Relevance 0

General Comments

This test has worked.