INT269873

Context Info Confidence 0.34 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.31 Pain Relevance 0

transport (Smad3) intracellular (Smad3) DNA binding (Smad3) protein complex (Smad3) cytoplasm (Smad3) nucleus (Smad3)

Smad3 (Mus musculus)

Pain Link Frequency Relevance Heat ketamine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Repression 7 100.00 Targeted Disruption 4 5.00 Hyperplasia 2 5.00 Injury 2 5.00 Exsanguination 1 5.00 Apoptosis 1 5.00 Breast Cancer 1 5.00 Cancer 1 5.00 Hypoglycemia 1 5.00 Colon Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Together, these data suggest that, although it is not required for binding to Smad3, the N-terminus of Sox17 is important for repression of Smad3 transcriptional activity.

Positive_regulation (important) of Negative_regulation (repression) of Smad3 associated with repression

1) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.31 Pain Relevance 0

General Comments

This test has worked.