INT269876

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.72
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sox17) DNA binding (Sox17) transcription factor binding (Sox17)
Anatomy Link Frequency
colon 1
MH1 1
Sox17 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 6 100.00 Very High Very High Very High
Repression 42 97.76 Very High Very High Very High
Breast Cancer 6 94.16 High High
Hypoglycemia 6 84.64 Quite High
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Hyperplasia 12 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low
Exsanguination 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, Sox17 interaction with these domains is consistent with the antagonistic effects of Sox17 on Smad3 DNA binding and transcriptional activity.
Sox17 Binding (interaction) of
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.13 Pain Relevance 0
Together, these findings indicate that the N-terminus of Sox17 containing the HMG domain is important for influencing the transcriptional responses of signaling pathways and that there may be multiple regions of Sox17 that contribute to complex protein interactions.
Sox17 Binding (terminus) of
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
To determine if the interaction between Sox17 and TGF-?
Sox17 Binding (interaction) of
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.31 Pain Relevance 0
In addition, Sox17 and Sox4 respectively inhibit and enhance proliferation of colon carcinoma cells through physical interactions with ?
Sox17 Binding (interactions) of in colon associated with colon cancer
4) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.28 Pain Relevance 0
While both the MAD homology domains (MH1 and MH2) of Smad3 interacted with Sox17 at low stringency binding conditions (data not shown), Smad3 1–145 did not bind to Sox17 under higher stringency conditions (Fig. 7B).
Sox17 Neg (not) Binding (bind) of in MH1
5) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
A truncated Sox17 isoform (t-Sox17), which lacks most of the HMG box and cannot bind DNA [34], did not affect cyclin D1 promoter activity (Fig. 6C), indicating that activation of cyclin D1-luciferase reporters by Sox17 requires DNA binding.
t-Sox17 Binding (binding) of
6) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0

General Comments

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