INT269878

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sox17) DNA binding (Sox17) transcription factor binding (Sox17)
Anatomy Link Frequency
lungs 4
epithelium 2
Sox17 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 6 19.68 Low Low
Repression 21 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Exsanguination 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Breast Cancer 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Hypoglycemia 3 5.00 Very Low Very Low Very Low
Colon Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endogenous expression of Sox17 was detected in endothelial cells in the peripheral lung but not in airway epithelial cells.
Negative_regulation (detected) of Gene_expression (expression) of Sox17 in lung
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
In addition to increased expression of Sox17 (data not shown), mRNAs for the cyclin-dependent kinase inhibitors p15, p21, and p57 were significantly decreased in lungs of CCSPrtTA/tetO-Sox17 mice relative to CCSPrtTA controls following 1 day of exposure to Dox (Fig. 5).
Negative_regulation (decreased) of Gene_expression (expression) of Sox17 in lungs
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Together these data show that prolonged expression of Sox17 in the adult mouse lung dramatically influences respiratory epithelial cell differentiation, generating ectopic structures in the peripheral lung with characteristics of the more proximal bronchiolar epithelium.


Negative_regulation (prolonged) of Gene_expression (expression) of Sox17 in epithelium
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0

General Comments

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