INT269882

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sox17) DNA binding (Sox17) transcription factor binding (Sox17)
Anatomy Link Frequency
epithelial cells 4
respiratory 4
Sox17 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 20 89.28 High High
Hyperplasia 10 52.56 Quite High
Repression 35 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low
Exsanguination 5 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Breast Cancer 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Hypoglycemia 5 5.00 Very Low Very Low Very Low
Colon Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the effects of prolonged expression of Sox17 in respiratory epithelial cells, adult CCSPrtTA/tetO-Sox17 mice were maintained on Dox for 12 months.
Spec (determine) Regulation (effects) of Gene_expression (expression) of Sox17 in epithelial cells
1) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Bronchiolar-like lesions are induced in the alveoli following prolonged Sox17 expression
Regulation (prolonged) of Gene_expression (expression) of Sox17
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
To determine if alveolar cells become permanently respecified following ectopic Sox17 expression, Sox17 was conditionally expressed in respiratory epithelial cells of adult mice.
Spec (determine) Regulation (respecified) of Gene_expression (expression) of Sox17 in respiratory
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.09 Pain Relevance 0
Together these data show that prolonged expression of Sox17 in the adult mouse lung dramatically influences respiratory epithelial cell differentiation, generating ectopic structures in the peripheral lung with characteristics of the more proximal bronchiolar epithelium.


Regulation (influences) of Gene_expression (expression) of Sox17 in epithelium
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Sox17 expression is dynamically regulated during endoderm formation and the programming of embryonic stem cells toward respiratory epithelial cell lineages in vitro [10]–[12].
Regulation (regulated) of Gene_expression (expression) of Sox17 in respiratory
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.05 Pain Relevance 0

General Comments

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