INT269891

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sox17) DNA binding (Sox17) transcription factor binding (Sox17)
Anatomy Link Frequency
Lungs 4
proximal 2
alveolar cell 2
epithelium 2
Sox17 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 8 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 16 99.28 Very High Very High Very High
Targeted Disruption 32 97.56 Very High Very High Very High
Cancer 8 61.00 Quite High
Injury 16 17.20 Low Low
Repression 56 5.00 Very Low Very Low Very Low
Exsanguination 8 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low
Hypoglycemia 8 5.00 Very Low Very Low Very Low
Colon Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Constitutive expression of Sox17 in human embryonic stem cells is sufficient to commit cells to the definitive endoderm lineage, and increased expression of Sox17 is associated with the differentiation of embryonic stem cells toward cells with characteristics of the respiratory epithelium [5], [6], [10]–[12].
Positive_regulation (increased) of Gene_expression (expression) of Sox17 in epithelium
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
In addition to increased expression of Sox17 (data not shown), mRNAs for the cyclin-dependent kinase inhibitors p15, p21, and p57 were significantly decreased in lungs of CCSPrtTA/tetO-Sox17 mice relative to CCSPrtTA controls following 1 day of exposure to Dox (Fig. 5).
Positive_regulation (increased) of Gene_expression (expression) of Sox17 in lungs
2) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
The GST-Sox17 and GST-Smad3 fusion proteins (and GST only) were expressed in BL21 cells induced with 1 mM isopropyl ?
Positive_regulation (-) of Gene_expression (expressed) of Sox17
3) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.06 Pain Relevance 0
Bronchiolar-like lesions are induced in the alveoli following prolonged Sox17 expression
Positive_regulation (following) of Gene_expression (expression) of Sox17
4) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Lungs from CCSPrtTA/tetO-Sox17 and CCSPrtTA single transgenic control mice were harvested after 4 weeks exposure to doxycycline (Dox) or following removal of Dox for 1 week, and were examined for expression of Sox17 and the proximal airway epithelial cell markers CCSP (Clara cells) and Foxj1 (ciliated cells).
Spec (examined) Positive_regulation (examined) of Spec (examined) Gene_expression (expression) of Sox17 in Lungs associated with targeted disruption
5) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.10 Pain Relevance 0
Expression of Sox17 in peripheral respiratory epithelial cells induced the formation of atypical alveolar cell clusters which contained cells that expressed conducting airway epithelial cell markers CCSP and Foxj1 (Fig. 1B,E,H).
Positive_regulation (induced) of Gene_expression (Expression) of Sox17 in alveolar cell
6) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.09 Pain Relevance 0
While conditional misexpression of Sox17 in respiratory epithelial cells of the embryonic mouse lung disrupted branching and differentiation of proximal/distal epithelial cell types, expression of Sox17 in the adult lung epithelium induced the formation of hyperplastic cell clusters in the alveolar region that contained cells expressing markers characteristic of diverse proximal airway epithelial lineages [13].
Positive_regulation (induced) of Gene_expression (expression) of Sox17 in proximal associated with hyperplasia
7) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.10 Pain Relevance 0
The formation of cell clusters in the alveolar regions was evident 5 days after the induction of Sox17 expression (Fig. 3F).
Positive_regulation (induction) of Gene_expression (expression) of Sox17
8) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.05 Pain Relevance 0

General Comments

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