INT269893

Context Info Confidence 0.18 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.86 Pain Relevance 0.04

nucleus (Pcna) intracellular (Pcna) DNA binding (Pcna) transcription factor binding (Pcna) cytoplasm (Pcna)

Pcna (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 3 76.60 colic 1 5.00 neuralgia 1 5.00 ketamine 1 5.00 anesthesia 1 5.00 Rheumatism 1 5.00

Disease Link Frequency Relevance Heat Pancreatic Cancer 15 90.24 Cancer 23 77.20 INFLAMMATION 3 76.60 Apoptosis 33 76.56 Death 16 75.76 Hypoglycemia 1 75.32 Colon Cancer 1 65.80 Breast Cancer 1 56.76 Repression 7 49.28 Targeted Disruption 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recent studies have shown that post-mitotic cells can reenter the cell cycle by blocking the expression of cyclin-dependent kinase inhibitors, supporting a role for this protein family in maintaining the balance between quiescence and proliferation [54].

Negative_regulation (blocking) of Gene_expression (expression) of cyclin

1) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.20 Pain Relevance 0

Western blot analyses indicated that [6]-gingerol decreased both Cyclin A and Cyclin-dependent kinase (Cdk) expression.

Negative_regulation (decreased) of Gene_expression (expression) of Cyclin

2) Confidence 0.01 Published 2006 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2687755 Disease Relevance 0.67 Pain Relevance 0.04

General Comments

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