INT269896

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.15
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) intracellular (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Anatomy Link Frequency
chondrocytes 4
articular 2
MC3T3-E1 2
F4/80 2
Smad2 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 76 98.08 Very High Very High Very High
agonist 50 97.36 Very High Very High Very High
antagonist 8 86.52 High High
Osteoarthritis 364 71.04 Quite High
Inflammation 48 50.00 Quite Low
cytokine 27 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 83 98.08 Very High Very High Very High
Hypertrophy 20 97.32 Very High Very High Very High
Sclerosis 8 96.32 Very High Very High Very High
Targeted Disruption 8 95.00 High High
Ureteral Obstruction 32 89.00 High High
Osteoarthritis 384 71.04 Quite High
Aging 52 70.76 Quite High
Chronic Renal Failure 4 54.36 Quite High
Disease 55 53.80 Quite High
Osteoporosis 11 50.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemistry showed that even a low TSA dose (10 nM) suppressed translocation of pSmad2 to the nuclei whereas high doses of TSA (200 and 500 nM) eliminated the pSmad2 signal from the cell nuclei as no pSmad2 expression was detected in the cell nuclei at these 2 TSA doses.
Positive_regulation (detected) of Neg (no) Gene_expression (expression) of pSmad2
1) Confidence 0.40 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0
In addition, overexpression of constitutive active ALK5 (Smad2/3) results in increased expression of aggrecan while constitutive ALK1 (Smad1/5/8) expression leads to elevated expression of MMP-13.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Smad2
2) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.26 Pain Relevance 0.06
1 signaling indicates that it acts primarily via pSMAD2, we observed in the MC3T3-E1 system that exogenous TGF-?
Positive_regulation (primarily) of Gene_expression (acts) of pSMAD2 in MC3T3-E1
3) Confidence 0.27 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.12 Pain Relevance 0.03
Since Smad2/3 are the transcriptional effectors of TGF-?
Positive_regulation (Since) of Gene_expression (/) of Smad2
4) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
on chondrocyte maturation is mediated by the Smad2/3 pathway, as has been shown by overexpression of dominant negative Smad2 and Smad3 in chondrocytes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Smad2 in chondrocyte
5) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.20 Pain Relevance 0
Overexpression of both Smad2 and Smad3 blocked spontaneous maturation in Smad3-deficient chondrocytes [70,71].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Smad2 in chondrocytes
6) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.18 Pain Relevance 0.03
In articular chondrocytes treated with azacytidine, reduced Smad2 and Smad3 expression and signaling and increased Smad1/5 expression correlated with elevated synthesis of type X collagen and alkaline phosphatase.
Positive_regulation (increased) of Gene_expression (expression) of Smad2 in articular
7) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.44 Pain Relevance 0.03
The immunohistochmistry of PAI-1, F4/80 and p-Smad2 demonstrated that their expressions were increased in CONT group and decreased in the all treated groups compared to CONT.
Positive_regulation (increased) of Gene_expression (expressions) of Smad2 in F4/80
8) Confidence 0.23 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2799997 Disease Relevance 0.60 Pain Relevance 0.37
Our findings showed that the p-Smad2 expression was also decreased in the PPAR?
Positive_regulation (-) of Gene_expression (expression) of Smad2
9) Confidence 0.23 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2799997 Disease Relevance 0.35 Pain Relevance 0.17

General Comments

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