INT269897

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccne1) cell cycle (Ccne1) cell division (Ccne1)
kinase activity (Ccne1) cytoplasm (Ccne1)
Anatomy Link Frequency
IEC-6 1
lungs 1
Ccne1 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 1 11.76 Low Low
spastic colon 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 47.08 Quite Low
Obesity 2 19.28 Low Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 12.08 Low Low
Disease 3 11.76 Low Low
Gastrointestinal Disease 3 11.00 Low Low
Repression 7 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblotting of IEC-6 cells demonstrated that CCNE1, CDK2, CREB1 are induced at the protein level upon miR-103 inhibition, further supporting an effect of miR-103 regulation on these genes.
Positive_regulation (induced) of CCNE1 in IEC-6
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0 Pain Relevance 0
Consistent with the induction of proliferation observed by immunohistochemistry (Fig. 3), transcripts for genes that promote cell cycle progression, including Foxm1, cyclin A2, cyclin B1, cyclin D1, and cyclin E1, were increased in lungs of CCSPrtTA/tetO-Sox17 mice after 3 days of Dox treatment (Fig. 5).
Positive_regulation (increased) of cyclin E1 in lungs
2) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0

General Comments

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