INT2699

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Context Info
Confidence 0.48
First Reported 1979
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 40
Total Number 42
Disease Relevance 7.07
Pain Relevance 33.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
brain 5
fat 2
spinal cord 2
DRG 2
bone marrow 1
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 211 100.00 Very High Very High Very High
narcan 35 100.00 Very High Very High Very High
Dynorphin 33 100.00 Very High Very High Very High
Dopamine 24 100.00 Very High Very High Very High
agonist 23 100.00 Very High Very High Very High
tolerance 22 100.00 Very High Very High Very High
medulla 16 100.00 Very High Very High Very High
Action potential 6 100.00 Very High Very High Very High
dorsal root ganglion 18 99.82 Very High Very High Very High
Opioid 26 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 19 99.82 Very High Very High Very High
Osteogenic Sarcomas 128 99.80 Very High Very High Very High
Neuroblastoma 4 99.76 Very High Very High Very High
Disease 28 99.72 Very High Very High Very High
Stress 4 97.68 Very High Very High Very High
Recurrence 54 97.56 Very High Very High Very High
Drug Dependence 1 96.80 Very High Very High Very High
Cancer 152 96.12 Very High Very High Very High
Breast Cancer 12 95.16 Very High Very High Very High
Alcohol Addiction 1 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, POMC and PE are sorted to the RSP at the TGN by a mechanism involving the interaction of a specific sorting signal on these molecules with the sorting receptor, CPE.
CPE Binding (interaction) of
1) Confidence 0.48 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12438160 Disease Relevance 0 Pain Relevance 0
Leu-enkephalin, tamoxifen and ethanol interactions: effects on motility and hepatic ethanol metabolizing enzymes.
Leu-enkephalin Binding (interactions) of associated with enkephalin
2) Confidence 0.43 Published 1990 Journal Gen. Pharmacol. Section Title Doc Link 2298389 Disease Relevance 0.14 Pain Relevance 0.43
In addition, the Cpefat/Cpefat activity does not bind to a substrate affinity column under conditions that bind CPE.
CPE Neg (not) Binding (bind) of
3) Confidence 0.42 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8940036 Disease Relevance 0 Pain Relevance 0.16
The acidic residues of these sorting signals bind specifically to basic residues on the sorting receptor membrane, carboxypeptidase E (CPE), to effect sorting to the RSP.
carboxypeptidase E Binding (bind) of
4) Confidence 0.36 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12438160 Disease Relevance 0 Pain Relevance 0
Significant naloxone/enkephalin interactions occurred in opioid-sensitive (18:00 h) samples of unseparated bone marrow.
enkephalin Binding (interactions) of in bone marrow associated with narcan, enkephalin and opioid
5) Confidence 0.36 Published 1995 Journal Biomed. Pharmacother. Section Abstract Doc Link 7749076 Disease Relevance 0 Pain Relevance 1.22
The acidic residues of these sorting signals bind specifically to basic residues on the sorting receptor membrane, carboxypeptidase E (CPE), to effect sorting to the RSP.
CPE Binding (bind) of
6) Confidence 0.35 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12438160 Disease Relevance 0 Pain Relevance 0
In addition, the Cpefat/Cpefat activity does not bind to a substrate affinity column under conditions that bind CPE.
CPE Binding (bind) of
7) Confidence 0.31 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8940036 Disease Relevance 0 Pain Relevance 0.16
To clarify these interactions, we here determined the levels of Met-enkephalin in striatal interstitial fluid (ISF) by microdialysis, striatal tissue homogenates, and serum after chronic ethanol treatment and alcohol withdrawal.
Met-enkephalin Binding (interactions) of associated with enkephalin, withdrawal and alcohol
8) Confidence 0.28 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.19 Pain Relevance 0.86
Responses of DRG neurons to dynorphin differed from responses to the opioid peptides leucine-enkephalin, which binds preferentially to delta-opiate receptors, and morphiceptin, which binds preferentially to mu-opiate receptors.
leucine-enkephalin Binding (binds) of in DRG associated with dorsal root ganglion, dynorphin, opiate, enkephalin and opioid
9) Confidence 0.28 Published 1984 Journal Neurosci. Lett. Section Abstract Doc Link 6146120 Disease Relevance 0.37 Pain Relevance 1.39
Interaction of Met-enkephalin and corticosteroids in immunomodulation.
Met-enkephalin Binding (Interaction) of associated with corticosteroid and enkephalin
10) Confidence 0.27 Published 1992 Journal Int. J. Immunopharmacol. Section Title Doc Link 1325954 Disease Relevance 0 Pain Relevance 0.77
Immunocytochemistry using an antibody which recognizes pro-enkephalin and high pressure liquid chromatography (HPLC) followed by radioimmunoassay indicated that pro-enkephalin was synthesized in these cells and processed to yield the bioactive pentapeptide, [Met]-Enk.
pro-enkephalin Binding (recognizes) of associated with enkephalin
11) Confidence 0.23 Published 1995 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8674823 Disease Relevance 0.16 Pain Relevance 0.61
First, many DRG neurons responded to dynorphin A but not to morphiceptin or Leu-enkephalin.
Leu-enkephalin Binding (responded) of in DRG associated with dorsal root ganglion, dynorphin and enkephalin
12) Confidence 0.21 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2409273 Disease Relevance 0.78 Pain Relevance 1.75
The increase of leucine enkephalin in the Wobbler spinal cord correlates significantly with age and with the progress of the disease, but leucine enkephalin declines slightly with age in the controls.
enkephalin Binding (declines) of in spinal cord associated with enkephalin, disease and spinal cord
13) Confidence 0.21 Published 1992 Journal Neuroscience Section Abstract Doc Link 1383870 Disease Relevance 0.67 Pain Relevance 1.73
Characterization of the association of tritiated enkephalin with neuroblastoma cells under conditions optimal for receptor down regulation.
enkephalin Binding (association) of associated with neuroblastoma and enkephalin
14) Confidence 0.18 Published 1983 Journal J. Biol. Chem. Section Title Doc Link 6296070 Disease Relevance 0.19 Pain Relevance 0.45
Oxytocin blocks the development of heroin-enkephalin cross-tolerance in mice.
heroin-enkephalin Binding (cross-tolerance) of associated with analgesic, tolerance and enkephalin
15) Confidence 0.18 Published 1992 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 1409803 Disease Relevance 0.09 Pain Relevance 1.18
A similar effect was observed after intracerebroventricular administration of oxytocin, supporting our assumption that oxytocin blocks the development of heroin-enkephalin cross-tolerance via CNS mechanisms.
heroin-enkephalin Binding (cross-tolerance) of associated with tolerance, enkephalin and intracerebroventricular
16) Confidence 0.18 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1409803 Disease Relevance 0.08 Pain Relevance 0.86
Peripheral treatment with oxytocin blocked the development of heroin-enkephalin cross-tolerance.
heroin-enkephalin Binding (cross-tolerance) of associated with tolerance and enkephalin
17) Confidence 0.18 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1409803 Disease Relevance 0.09 Pain Relevance 0.89
A similar effect was observed after intracerebroventricular administration of oxytocin, supporting our assumption that oxytocin blocks the development of heroin-enkephalin cross-tolerance via CNS mechanisms.
heroin-enkephalin Binding (cross-tolerance) of associated with tolerance, enkephalin and intracerebroventricular
18) Confidence 0.18 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1409803 Disease Relevance 0.08 Pain Relevance 0.86
Methionine enkephalin increases faster in Wobbler brainstem and decreases faster in control spinal cord with age.
enkephalin Binding (decreases) of in spinal cord associated with medulla, enkephalin and spinal cord
19) Confidence 0.18 Published 1992 Journal Neuroscience Section Abstract Doc Link 1383870 Disease Relevance 0.70 Pain Relevance 1.75
Interactions with naloxone and the enkephalin analogue, FK 33-824.
enkephalin Binding (Interactions) of associated with narcan and enkephalin
20) Confidence 0.17 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 6328330 Disease Relevance 0 Pain Relevance 0.52

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