INT269900

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxj1) DNA binding (Foxj1) transcription factor binding (Foxj1)
Anatomy Link Frequency
alveolar cell 2
proximal 1
epithelial cell 1
Lungs 1
Foxj1 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 24 97.30 Very High Very High Very High
Repression 42 5.00 Very Low Very Low Very Low
Hyperplasia 12 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low
Exsanguination 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Breast Cancer 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Hypoglycemia 6 5.00 Very Low Very Low Very Low
Colon Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More notable, neither the alveolar cell clusters nor peripheral expression of CCSP or Foxj1 were observed in lungs from these mice (Fig. 1C,F,I).
Gene_expression (expression) of Foxj1 in alveolar cell
1) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.07 Pain Relevance 0
Thus, the Sox17-induced bronchiolar-like structures contained a mixed population of cells that expressed CCSP, Foxj1, Sca-1, CCSP+/Sca-1+, and CCSP+/proSP-C+, consistent with reprogramming of progenitor cells along several differentiated pathways.
Gene_expression (expressed) of Foxj1
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
The bronchiolar-like structures expressed Sox17 (Fig. 2B) and contained subsets of cells that expressed proximal airway epithelial markers CCSP and Foxj1 (Fig. 2C–D), consistent with bronchiolar cell differentiation.
Gene_expression (expressed) of Foxj1 in proximal
3) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Foxa1, Foxa2, and GATA6 influence the expression of differentiated respiratory epithelial cell markers, including CCSP and Foxj1 [42]–[44].
Gene_expression (expression) of Foxj1 in epithelial cell
4) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Expression of Sox17 in peripheral respiratory epithelial cells induced the formation of atypical alveolar cell clusters which contained cells that expressed conducting airway epithelial cell markers CCSP and Foxj1 (Fig. 1B,E,H).
Gene_expression (expressed) of Foxj1 in alveolar cell
5) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.08 Pain Relevance 0
Lungs from CCSPrtTA/tetO-Sox17 and CCSPrtTA single transgenic control mice were harvested after 4 weeks exposure to doxycycline (Dox) or following removal of Dox for 1 week, and were examined for expression of Sox17 and the proximal airway epithelial cell markers CCSP (Clara cells) and Foxj1 (ciliated cells).
Spec (examined) Gene_expression (expression) of Foxj1 in Lungs associated with targeted disruption
6) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.10 Pain Relevance 0

General Comments

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